文献类型：期刊文献

中文题名：揿针联合维生素D对孤独症谱系障碍儿童行为及胃肠道症状的临床研究

英文题名：Clinical Study of Acupuncture Combined with Vitamin D on Behavioral and Gastrointestinal Symptoms in Children with Autism Spectrum Disorder

作者：顾建辉[1];景玉珍[1];路军锋[1];杨丽娜[2];魏清琳[3];贾永男[2]

第一作者：顾建辉

机构：[1]甘肃省康复中心医院儿童康复科,甘肃省兰州市730000;[2]甘肃中医药大学附属医院北院针灸科,甘肃省兰州市730000;[3]甘肃中医药大学附属医院针灸中心,甘肃省兰州市730000

第一机构：甘肃省康复中心医院儿童康复科,甘肃省兰州市730000

年份：2025

卷号：28

期号：33

起止页码：4180

中文期刊名：中国全科医学

外文期刊名：Chinese General Practice

收录：;北大核心:【北大核心2023】；

基金：甘肃省卫生健康行业科研管理项目(GSWSKY2021-072);甘肃省青年科技基金计划项目(20JR10RA347)。

语种：中文

中文关键词：孤独症谱系障碍;维生素D;揿针;儿童;行为症状;胃肠道

外文关键词：Autism spectrum disorder;Vitamin D;Acupuncture;Child;Behavior symptoms;Gastrointestinal tract

摘要：背景特殊教育康复治疗是改善孤独症谱系障碍(ASD)核心症状的主要方法,但大部分ASD儿童存在便秘、腹痛、恶心等胃肠道功能失调的共患病,严重影响了ASD儿童的身心健康。揿针可改善胃肠道功能,维生素D(VitD)参与神经系统发育及免疫调节,与ASD儿童症状及功能密切相关;而揿针联合VitD治疗ASD儿童行为及胃肠道症状的疗效有待研究。目的在特殊教育康复治疗的基础上,探讨揿针联合VitD对ASD儿童行为及胃肠道症状的影响。方法选取2022年4月—2024年6月就诊于甘肃省康复中心医院、甘肃中医药大学附属医院进行康复训练的ASD儿童84例为研究对象,依据随机数字表法随机分成2组(观察组和对照组各42例),依据剔除标准最终各组纳入40例。对照组运用特殊教育康复治疗方法,观察组在特殊教育康复治疗基础上运用揿针联合VitD2治疗,2组均治疗3个月。观察并比较2组ASD儿童治疗前后孤独行为评定量表(ABC)、儿童孤独症评定量表(CARS)、社交反应量表(SRS)、中医胃肠道症状评分和血清25-羟维生素D[25-(OH)D]水平,并以此评定2组干预方法的疗效。结果与治疗前相比,2组ASD儿童治疗后ABC、CARS、SRS、中医胃肠道症状评分均降低(P<0.05);治疗后,观察组ASD儿童ABC、CARS、SRS、中医胃肠道症状评分均低于对照组(P<0.05)。与治疗前相比,对照组ASD儿童治疗后25-(OH)D水平下降,观察组治疗后25-(OH)D水平上升(P<0.05);治疗后,观察组ASD儿童25-(OH)D水平高于对照组(P<0.05)。观察组总有效36例(90.0%),对照组总有效30例(75.0%),观察组总有效率高于对照组(P<0.05)。结论揿针联合VitD治疗ASD儿童疗效显著,能够有效改善儿童社会交往及行为能力,减轻胃肠道不适症状,提升生活质量,提高康复训练效果。
Background Special education rehabilitation therapy is the main method to improve the core symptoms of autism spectrum disorder(ASD);however,most children with ASD have comorbid gastrointestinal dysfunction such as constipation,abdominal pain,and nausea,which severely affect their physical and mental health.Snap shots improve gastrointestinal function,and vitamin D(VitD)is involved in neurological development and immune regulation is closely related to symptoms and function in children with ASD;and the efficacy of snap needles combined with VitD in treating behavioral and gastrointestinal symptoms in children with ASD needs to be studied.Objective To observe the effects of acupuncture combined with VitD on behaviors and gastrointestinal symptoms in autistic children based on special education rehabilitation therapy.Methods A total of 84 children with ASD who received rehabilitation training in Gansu Province Hospital Rehabilitation Center and Affiliated Hospital of Gansu University of Chinese Medicine from April 2022 to June 2024 were selected as the research objects.They were randomly divided into two groups(42 cases in the observation group and 42 cases in the control group)according to the random number table method.Finally,40 cases were included in each group after exclusion criteria.The control group was treated with special education rehabilitation therapy,while the observation group was treated with press-needle combined with vitamin D2 on the basis of special education rehabilitation therapy.Both groups were treated for 3 months.The Autism Behavior Checklist(ABC),Childhood Autism Rating Scale(CARS),Social Responsiveness Scale(SRS),TCM Gastrointestinal Symptom Scores and serum 25-hydroxyvitamin D[25-(OH)D]levels of the two groups of ASD children before and after treatment were observed and compared to evaluate the efficacy of the intervention methods in the two groups.Results Compared with before treatment,the scores of ABC,CARS,SRS and TCM Gastrointestinal Symptom in both groups of ASD children decreased after treatment(P<0.05);after treatment,the scores of ABC,CARS,SRS and TCM Gastrointestinal Symptom in the observation group were lower than those in the control group(P<0.05).Compared with before treatment,the level of 25-(OH)D in the control group decreased after treatment,while that in the observation group increased(P<0.05);after treatment,the level of 25-(OH)D in the observation group was higher than that in the control group(P<0.05).The total effective cases in the observation group were 36(90.0%),and 30(75.0%)in the control group.The total effective rate of the observation group was higher than that of the control group(P<0.05).Conclusion Acupuncture combined with VitD has a significant therapeutic effect on children with autism,effectively improving children's social interaction and behavior abilities,alleviating gastrointestinal discomfort,enhancing quality of life,and improving rehabilitation training outcomes.