文献类型：期刊文献

英文题名：Overexpression of IL-8 and Wnt2 is associated with prognosis of gastric cancer

作者：Lin, Li[1];Li, Linjing[2];Ma, Gui[3];Kang, Yaqiong[3];Wang, Xingdong[4];He, Jianxin[5]

第一作者：Lin, Li

通信作者：Lin, L[1]

机构：[1]Gansu Prov Matern & Child Care Hosp, Dept Hematol & Oncol, Lanzhou 730050, Gansu, Peoples R China;[2]Lanzhou Univ, Dept Clin Lab Ctr, Hosp 2, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Prov Canc Hosp, Dept Pathol, Lanzhou 730050, Gansu, Peoples R China;[4]Gansu Prov Canc Hosp, Dept Intervent Therapy, Lanzhou 730050, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Basic Med Coll, Lanzhou 730000, Gansu, Peoples R China

第一机构：Gansu Prov Matern & Child Care Hosp, Dept Hematol & Oncol, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Matern & Child Care Hosp, Dept Hematol & Oncol, Lanzhou 730050, Gansu, Peoples R China.

年份：2022

卷号：60

期号：1

起止页码：66

外文期刊名：FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

收录：;Scopus(收录号：2-s2.0-85127177099);WOS:【SCI-EXPANDED(收录号:WOS:000775965200001)】；

基金：This work was funded by the National Natural Science Foundation of China (NO. 82060531) , the Project of Scientific and technical guidance of Lanzhou, Gansu Province, China (grant number: 2018-ZD-39) , and the Young Talents Innovation Projects from YGansu Provincial Cancer Hospital, Gansu Provincial Aca-demic Institute for Medical Research, China (grant number: ykz-2018-1) .

语种：英文

外文关键词：gastric cancer; interleukin-8; Wnt2; prognosis; IHC

摘要：Introduction. This study is to detect the expression of inflammatory factor or neutrophil-activating factor IL-8 and Wnt2 in gastric cancer (GC) and investigate the involvement of IL-8 and Wnt2 expressions in the clinico-pathological indexes and prognosis. Material and methods. We detected the expression of IL-8 and Wnt2 in 100 GC tissues and 40 normal gastric mucosae using immunohistochemistry. The relationships between the IL-8 and Wnt2 expression and the clin-icopathological characteristics were explored. The relationship between IL-8 expression, Wnt2 expression, and prognosis of GC was analyzed by survival curve and survival regression. Results. The expression of IL-8 and Wnt2 in GC tissue was 64% and 75% respectively, which was significantly higher than that in adjacent normal gastric mucosa tissues, moreover, expressions of IL-8 and Wnt2 were pos-itively correlated. The positive rate of IL-8 and Wnt2 expressions were correlated with lymph node metastasis and TNM staging P < 0.01, and Wnt2 was also correlated with infiltration depth (P = 0.021), but there was no difference with age, sex, and differentiation (P > 0.05). The 3-year survival analysis showed that the survival rates of IL -8-and Wnt2-positive patients were 20% and 24%, respectively, which were significantly lower than those of negative patients. Cox regression analysis showed that IL-8 and Wnt2 may be independent factors affecting the prognosis of GC. Conclusions. Our data demonstrated that the overexpression of IL-8 and Wnt2 could be isolated prognostic factors in patients with GC and, possibly, may present new targets for the treatment of GC.