文献类型：期刊文献

英文题名：High FN1 expression correlates with gastric cancer progression

作者：Li, Junliang[1,2,3];Chen, Cheng[4];Chen, Bo[5];Guo, Tiankang[1,2]

第一作者：Li, Junliang;李菊莲

通信作者：Guo, TK[1];Guo, TK[2]

机构：[1]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Gen Surg, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China;[4]Gansu Prov Hosp, Dept Pathol, Lanzhou, Gansu, Peoples R China;[5]Gansu Prov Hosp, Dept Ultrasound Diag, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Gen Surg, Lanzhou, Gansu, Peoples R China.

年份：2022

卷号：239

外文期刊名：PATHOLOGY RESEARCH AND PRACTICE

收录：;Scopus(收录号：2-s2.0-85140083573);WOS:【SCI-EXPANDED(收录号:WOS:000889315400003)】；

基金：This study was supported by the Natural Science Foundation of Gansu Province (20JR10RA372) , Health Industry Research Project of Gansu Province (GSWSKY-2019-03) , National scientific research project support program of Gansu Provincial Hospital (19SYPYB-10) , Open fund project of Gansu Key Laboratory of Molecular Diagnosis and Precision Therapy of Surgical Oncology (2020GSZDSYS02) , Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320005) , Scientific Research and Innovation Fund of Gansu University of Chinese Medicine (2020KCYB-7) , and Longyuan Youth Innovation and Entrepreneurship Talent Project (111266548053) .

语种：英文

外文关键词：Fibronectin 1; Gastric cancer; Immunohistochemistry; Survival; Stroma; Prognosis

摘要：Objective: High stromal ratio of gastric cancer is associated with a poor prognosis. Fibronectin 1(FN1) is the main component of gastric cancer stroma. The focus of this research was to investigate the FN1 express pattern, the connection between FN1 expression, clinicopathological parameters, survival, and mismatch repair genes (MMR) or immune checkpoints in gastric cancer patients.Methods: Eighty-six paired stomach cancer tissues, neighboring normal tissues, and eight independent gastric cancer tissues were used to create 180 points tissue microarrays. The association between epithelial fibronectin (E-FN1), stromal fibronectin (S-FN1) expression, and clinical characteristics was analyzed using the chi-square test or Fisher's exact test, and the survival analysis curve was analyzed using the log-rank test, followed by univariate and multivariate Cox regression. The correlation between FN1 and MMR or immune checkpoints was analyzed by Spearman correlation. Results: FN1 is mainly expressed in gastric cancer tissues, with low or no expression in adjacent normal tissues. In tumor tissues, FN1 is mostly distributed in the stroma. High E-FN1 expression was associated with a decreased overall survival (OS), while S-FN1 expression did not. High S-FN1 expression correlated with older age (P<0.001), higher pathological grade (P<0.001), pathological type (P<0.001), vessel/lymphatic invasion (P<0.001), advanced T stage (P = 0.001), N stage (P = 0.01), and worse TNM stage(P = 0.033). FN1 expression was not associated with MMR or immune checkpoints (MLH1, MSH2, MSH6, PDL1, PD1, PMS2, and CD8).Conclusions: High E-FN1 expression predicted poor OS, while S-FN1 is associated with gastric cancer progression.