文献类型：期刊文献

中文题名：2型糖尿病的小脑磁共振成像研究进展

英文题名：Research progress on cerebellar magnetic resonance imaging in type 2 diabetes mellitus

作者：刘建荣[1];魏婧[1];赵莲萍[2]

第一作者：刘建荣

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]甘肃省人民医院放射科,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2026

卷号：17

期号：2

起止页码：142

中文期刊名：磁共振成像

外文期刊名：Chinese Journal of Magnetic Resonance Imaging

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金项目(编号:82360343);甘肃省自然科学基金项目(编号:25JRRA296);甘肃省人民医院院内科研项目(编号:2024KYQDJ-A-34)。

语种：中文

中文关键词：2型糖尿病;小脑;磁共振成像;结构磁共振成像;功能磁共振成像;认知功能障碍;情绪障碍;脑灌注

外文关键词：type 2 diabetes mellitus;cerebellum;magnetic resonance imaging;structural magnetic resonance;functional magnetic resonance imaging;cognitive impairment;emotional disorder;cerebral perfusion

摘要：2型糖尿病(type 2 diabetes mellitus,T2DM)相关的认知功能障碍已成为重要的公共卫生问题,其潜在的神经机制尚未完全阐明。近年来的研究逐渐揭示,小脑作为感觉运动整合与认知情绪调节的关键节点,在T2DM的中枢神经病理生理过程中扮演着不容忽视的角色。现有研究提示,小脑可能是T2DM中枢损害的易感区域,其结构与功能参数的异常很可能成为认知情绪障碍的早期影像学生物标志物。本文系统综述了基于磁共振成像(结构、功能及灌注成像)所揭示的T2DM患者小脑改变及其与认知情绪障碍的关联性证据,在此基础上,进一步指出当前研究的局限性,并据此探讨了今后的研究方向,旨在为全面理解T2DM状态下中枢神经系统的神经病理生理机制提供新视角,并为相关中枢神经并发症的早期识别与精准干预提供影像学依据。
Cognitive dysfunction associated with type 2 diabetes mellitus(T2DM)has emerged as a significant public health concern,the underlying neural mechanisms of which are not yet fully elucidated.Recent studies have progressively revealed that the cerebellum,as a critical node for sensorimotor integration and cognitive-emotional regulation,plays an indispensable role in the central nervous system pathophysiology of T2DM.Existing research indicates that the cerebellum may be a susceptible region for central nervous system damage in T2DM,and abnormalities in its structural and functional parameters are more likely to serve as early imaging biomarkers for cognitive decline,offering new perspectives for understanding disease mechanisms and facilitating early intervention.This paper systematically reviews evidence from magnetic resonance imaging(structural,functional,and perfusion imaging)regarding cerebellar alterations in T2DM patients and their association with cognitive and emotional disorders.Building upon this,the paper further highlights the limitations of existing research and proposes future research directions.The goal is to provide a novel perspective for a holistic understanding of the neuropathophysiological mechanisms of the central nervous system in the context of T2DM,and to furnish imaging evidence to support the early detection and precise management of associated central nervous system complications.