详细信息
老年阻塞性睡眠呼吸暂停低通气综合征相关高血压影响因素分析 被引量:9
Influencing factors of OSAHS-related hypertension in the elderly
文献类型:期刊文献
中文题名:老年阻塞性睡眠呼吸暂停低通气综合征相关高血压影响因素分析
英文题名:Influencing factors of OSAHS-related hypertension in the elderly
作者:赵力博[1,2];刘霖[3];李建华[1];徐伟豪[5];高莹卉[6];钱小顺[3];陈开兵[7];王亚斌[4];范利[4]
第一作者:赵力博
机构:[1]解放军总医院第二医学中心心血管内科,北京100853;[2]解放军总医院研究生院;[3]解放军总医院呼吸与危重症医学科,北京100853;[4]国家老年疾病临床医学研究中心;[5]海南省军区海口离职干部休养所;[6]北京大学国际医院睡眠中心;[7]甘肃中医药大学附属医院
第一机构:解放军总医院第二医学中心心血管内科,北京100853
年份:2021
卷号:23
期号:4
起止页码:372
中文期刊名:中华老年心脑血管病杂志
外文期刊名:Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
收录:CSTPCD;;北大核心:【北大核心2020】;
基金:军队保健专项科研基金(19BJZ34,16BJZ25);国家老年疾病临床研究中心开放课题(NCRCG-PLAGH-2018008);解放军总医院军事医学青年项目(QNC19054);解放军总医院第二医学中心专项科研课题(ZXD2008)。
语种:中文
中文关键词:睡眠呼吸暂停;阻塞性;多道睡眠描记术;高血压;尿酸;糖尿病
外文关键词:sleep apnea,obstructive;polysomnography;hypertension;uric acid;diabetes mellitus
摘要:目的探究老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)相关高血压的影响因素。方法入选经多导睡眠监测(PSG)诊断为OSAHS老年患者609例,按血压水平分为非高血压组174例和高血压组435例,比较2组PSG各指标的差异。采用Spearman相关性分析和多因素logistic回归分析。结果2组体质量指数(BMI)、呼吸暂停低通气指数(AHI)、血氧饱和度(SaO_2)<90%时间比较,差异有统计学意义(P<0.05,P<0.01)。年龄、BMI、最长暂停时间、SaO_2<90%时间、SaO_2<90%时间占总监测时间的百分比、TG、血糖、尿酸等与高血压呈正相关,HDL、总胆红素、平均SaO_2与高血压呈负相关(P<0.05,P<0.01)。logistic回归分析示,BMI、AHI、尿酸、糖尿病和总胆红素是OSAHS相关高血压的影响因素(OR=1.087、1.014、1.003、3.438和0.951,P<0.05,P<0.01)。年龄为女性相关高血压的影响因素(OR=1.103,P<0.05)。结论BMI、AHI、尿酸和糖尿病是老年OSAHS相关高血压的危险因素,总胆红素是其保护因素;增龄是此类女性患者的危险因素。
Objective To study the influencing factors of OSAHS-related hypertension in the elderly.Methods Six hundred and nine elderly OSAHS patients were divided into hypertension-free group(n=174)and hypertension group(n=435).The PSG indicators were compared and analyzed by Spearman correlation analysis and multivariate logistic regression analysis respectively.Results Significant differences were detected in BMI,AHI and SaO2<90%between the two groups(P<0.05,P<0.01).Age,BMI,SaO2<90%,SaO2<90%/total monitoring time ratio,serum TG,blood glucose and UA levels were positively related with hypertension while serum HDL and TB levels and mean SaO2 were negatively related with hypertension in elderly OSAHS patients(P<0.05,P<0.01).Logistic regression analysis showed that BMI,AHI,DM,serum UA and TB levels were the influencing factors of hypertension in elderly OSAHS patients(OR=1.087,OR=1.014,OR=1.003,OR=3.43,OR=0.951,P<0.05,P<0.01).Age was an influencing factor of hypertension in female OSAHS patients(OR=1.103,P<0.05).Conclusion BMI,AHI,DM and serum UA level are the risk factors for hypertension while serum TB level is a protective factor for hypertension in elderly OSAHS patients.Aging is a risk factor for hypertension in female OSAHS patients.
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