文献类型：期刊文献

中文题名：姜黄素改善脊髓损伤作用机制研究进展

英文题名：Research Progress of Mechanism of Curcumin in Improving Spinal Cord Injury

作者：史凡凡[1];赵继荣[1];蒋鹏[1];薛旭[2];赵宁[2];马同[2];杨涛[3]

第一作者：史凡凡

机构：[1]甘肃中医药大学,甘肃兰州730030;[2]甘肃省中医院,甘肃兰州730050;[3]甘肃中医药大学附属医院,甘肃兰州730030

第一机构：甘肃中医药大学

年份：2023

卷号：30

期号：12

起止页码：192

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；

基金：国家自然科学基金(81760877);甘肃省科技重大项目(21ZD4FA009);中医药循证能力建设项目(2019xzzxGK005);甘肃省科技计划(21JR7RA681)。

语种：中文

中文关键词：姜黄素;脊髓损伤;药理作用;综述

外文关键词：curcumin;spinal cord injury;pharmacological effect;review

摘要：脊髓损伤是最具破坏性的中枢性损伤之一,可引起受损部位以下肢体和躯干严重功能障碍。姜黄素因其抗炎、抗氧化、抗细胞凋亡等药理特性,近年来被广泛应用于神经系统疾病治疗。本文通过对相关研究成果系统总结,主要从调控炎症反应、氧化应激、细胞凋亡、脊髓微循环、胶质瘢痕形成、神经元再生方面对姜黄素保护脊髓损伤的作用机制进行综述,以期为姜黄素治疗脊髓损伤的创新药物研发与临床应用提供参考。
Spinal cord injury is one of the most devastating central injuries and can cause severe dysfunction of the limbs and trunk below the affected site.Curcumin has been widely used in the treatment of nervous system diseases in recent years due to its anti-inflammatory,antioxidant and anti-apoptosis pharmacological properties.Based on a systematic summary of relevant research results,this article mainly reviewed the mechanism of curcumin in protecting spinal cord injury from the aspects of regulating inflammation,oxidative stress,apoptosis,spinal cord microcirculation,glial scar formation,and neuron regeneration,in order to provide references for the development and clinical application of innovative drugs for curcumin in the treatment of spinal cord injury.