文献类型：期刊文献

英文题名：Omega-3 polyunsaturated fatty acids in the prevention of postoperative complications in colorectal cancer: a meta-analysis

作者：Xie, Hai[1];Chang, Yan-na[2]

第一作者：Xie, Hai

通信作者：Chang, YN[1]

机构：[1]Lanzhou Univ, Hosp 1, Dept Emergency, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Anesthesiol, 732 West Jiayuguan Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Hosp 1, Dept Emergency, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Anesthesiol, 732 West Jiayuguan Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2016

卷号：9

起止页码：7435

外文期刊名：ONCOTARGETS AND THERAPY

收录：;Scopus(收录号：2-s2.0-85006707412);WOS:【SCI-EXPANDED(收录号:WOS:000389956000001)】；

语种：英文

外文关键词：omega-3; fatty acids; fish oil; colorectal surgery; meta-analysis

摘要：Objective: To evaluate systematically the clinical efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in the prevention of postoperative complications in colorectal cancer (CRC) patients. Materials and methods: Published articles were identified by using search terms in online databases - PubMed, Embase, and the Cochrane Library - up to March 2016. Only randomized controlled trials investigating the efficacy of omega-3 PUFAs in CRC were selected and analyzed through a meta-analysis. Subgroup, sensitivity, and inverted funnel-plot analyses were also conducted. Results: Eleven articles with 694 CRC patients were finally included. Compared with control, omega-3 PUFA-enriched enteral or parenteral nutrition during the perioperative period reduced infectious complications (risk ratio [RR] 0.63, 95% confidence interval [CI] 0.47-0.86; P= 0.004), tumor necrosis factor alpha (standard mean difference [SMD] -0.37, 95% CI -0.66 to -0.07; P= 0.01), interleukin-6 (SMD -0.36, 95% CI -0.66 to -0.07; P= 0.02), and hospital stay (MD -2.09, 95% CI -3.71 to -0.48; P= 0.01). No significant difference was found in total complications, surgical site infection, or CD4(+): CD8(+) cell ratio. Conclusion: Short-term omega-3 PUFA administration was associated with reduced postoperative infectious complications, inflammatory cytokines, and hospital stay after CRC surgery. Due to heterogeneity and relatively small sample size, the optimal timing and route of administration deserve further study.