文献类型：期刊文献

英文题名：Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota

作者：Zhang, Li-Ying[1];Zhou, Ting[1];Zhang, Yi-Ming[1];Xu, Xiao-Min[1];Li, Yang-Yang[1];Wei, Kong-Xi[1];He, Jin-Peng[2,3];Ding, Nan[2,3];Zhou, Heng[2,3];Liu, Yong-Qi[1,4]

第一作者：张利英

通信作者：Liu, YQ[1];Liu, YQ[2]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Peoples R China;[2]Chinese Acad Sci, Key Lab Space Radiobiol Gansu Prov, Inst Modern Phys, Lanzhou 730000, Peoples R China;[3]Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2020

卷号：2020

外文期刊名：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

收录：;Scopus(收录号：2-s2.0-85096066638);WOS:【SCI-EXPANDED(收录号:WOS:000591545600003)】；

基金：The authors are grateful to Dr. Jufang Wang (the Key Laboratory of Space Radiobiology of Gansu Province and Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China) for her kind help of laboratory equipment. This study was supported by the National Natural Science Foundation of China (nos. 82004094 and 81973595), the Open Fund of Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment for Major Diseases for Colleges and Universities in Gansu Province (nos. FZYX14-4 and FZYX17-18-13), Collaborative Innovation Project of Chinese and Tibetan Medicine (no. XBXT2015-1), Project of Gansu Provincial Education Department (no. 2015A-095), and the Open Fund of Key Laboratory of Dunhuang Medicine and Transformation at Provincial and Ministerial Level (DHYX19-13).

语种：英文

摘要：The gut microbiota is important in metabolism and immune modulation, and compositional disruption of the gut microbiota population is closely associated with inflammation caused by ionizing radiation (IR). Guiqi Baizhu decoction (GQBZD) is a medicinal compound used in traditional Chinese medicine with anti-inflammatory and antioxidation effects, especially in the process of radiotherapy. However, the effect of GQBZD on reducing the damage to the normal immune system in radiotherapy remains unclear. Here, we show that GQBZD reduces body weights, water intake, food intake, diarrhea level and quality of life score, and inflammation and enhances immunity function in rats treated with X-ray radiation. Meanwhile, our data indicate that GQBZD not only reverses IR-induced gut dysbiosis as indicated change of alpha-diversity and beta-diversity of microbiota, the composition of Desulfovibrio, Bacteroides, and Parabacteroides, except for Roseburia and Lachnoclostridium, but also maintains intestinal barrier integrity and promoting the formation of short-chain fatty acids (SCFAs). GQBZD can also reduce the level of phosphorylation P65 (p-P65). Our results demonstrate that GQBZD can significantly alleviate the inflammatory responses and improve the immune damage against IR, and may be used as prebiotic agents to prevent gut dysbiosis and radiation-related metabolic disorders in radiotherapy.