文献类型：期刊文献

英文题名：The role of lncRNA NEAT1 in human cancer chemoresistance

作者：Long, Feng[1];Li, Xue[1];Pan, Jingyu[1];Ye, Hailin[1];Di, Cuixia[2];Huang, Yong[1];Li, Jiawei[1];Zhou, Xuan[1];Yi, Huiyi[1];Huang, Qiaozhen[1];Si, Jing[2]

第一作者：龙凤

通信作者：Si, J[1]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China;[2]Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou, Peoples R China.

年份：2024

卷号：24

期号：1

外文期刊名：CANCER CELL INTERNATIONAL

收录：;Scopus(收录号：2-s2.0-85197529053);WOS:【SCI-EXPANDED(收录号:WOS:001262971800001)】；

基金：This work was financially supported by the National Key R and D Program of China (2018YFE0205100), Open Project of Dunhuang Key Laboratory of Medicine and Translational Education (DHYX22-10), "Double First-Class" Key Research Projects in Gansu Province (GSSYLXM-01), Flagship Education Projects (2021jyjbgs-03), Innovation Fund Program for Higher Education Teachers(2024 A-088).

语种：英文

外文关键词：Cancer; Chemotherapy resistance; NEAT1; Mechanism of action

摘要：Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become an urgent problem to be solved in the field of cancer chemotherapy. Therefore, it is very important to deeply study and analyze the mechanism of cancer chemotherapy resistance and its regulatory factors. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) has been shown to be closely associated with chemotherapy resistance in cancer. NEAT1 induces cancer cell resistance to chemotherapeutic drugs by regulating cell apoptosis, cell cycle, drug transport and metabolism, DNA damage repair, EMT, autophagy, cancer stem cell characteristics, and metabolic reprogramming. This indicates that NEAT1 may be an important target to overcome chemotherapy resistance and is expected to be a potential biomarker to predict the effect of chemotherapy. This article summarizes the expression characteristics and clinical characteristics of NEAT1 in different cancers, and deeply discusses the regulatory role of NEAT1 in cancer chemotherapy resistance and related molecular mechanisms, aiming to clarify NEAT1 as a new target to overcome cancer chemotherapy resistance and the feasibility of chemotherapy sensitizers, with a view to providing a potential therapeutic direction for overcoming the dilemma of cancer resistance in the future.