文献类型：期刊文献

中文题名：“认知康复组穴”针刺联合多奈哌齐治疗肾精亏虚型卒中后轻度认知障碍的临床研究

英文题名：Clinical Study of Needling'Cognitive Rehabilitation Group Points'Combined with Donepezil in Treating Mild PSCI of Kidney-Essence Deficiency Syndrome

作者：谢亚青[1];毛忠南[2];张晓凌[2];王瑞瑞[1]

第一作者：谢亚青

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2021

卷号：38

期号：10

起止页码：53

中文期刊名：中医药信息

外文期刊名：Information on Traditional Chinese Medicine

基金：甘肃省中医药管理局科研立项课题(GZK-2017-19);2019年甘肃省重点人才项目(甘组通字〔2019〕39号)。

语种：中文

中文关键词：脑卒中;认知障碍;认知康复组穴;肾精亏虚证

外文关键词：Stroke;Cognitive impairment;Cognitive rehabilitation group points;Kidney-essence deficiency syndrome

摘要：目的:观察和评价“认知康复组穴”针刺联合多奈哌齐治疗肾精亏虚型卒中后轻度认知障碍患者的临床疗效,分析探讨该治疗方式对肾精亏虚型卒中后轻度认知障碍患者认知水平和生活能力的影响。方法:将符合纳入标准的62例患者用随机数字表分为“认知康复组穴”针刺联合多奈哌齐组(治疗组)与多奈哌齐组(对照组),各31例,两组患者均给予卒中后二级预防药物和常规康复训练。同时,对照组予以多奈哌齐10 mg口服,每日1次;治疗组在对照组的基础上予以“认知康复组穴”针刺治疗,每日1次,每周治疗6 d,两组疗程均为4周。治疗结束后观察两组治疗前后MMSE、MoCA、ADL量表评分及中医证候积分的变化,并比较两组疗效。结果:治疗后治疗组总有效率为90.32%(28/31),明显优于对照组的66.67%(20/30)(P<0.05);两组治疗后较治疗前MMSE、MoCA、ADL评分、中医证候积分均有明显提高(P<0.05),且治疗组各项评分均明显高于对照组(P<0.05)。结论:“认知康复组穴”针刺联合多奈哌齐与单纯使用多奈哌齐治疗肾精亏虚型卒中后轻度认知障碍均有明显的临床疗效,但前者临床疗效较单一西药治疗更显著。“认知康复组穴”针刺疗法在改善肾精亏虚证中医证候方面存在明显治疗优势,联合多奈哌齐治疗在提高患者认知及日常生活能力方面也优于西医单药治疗,可提高患者认知水平。
Objective:To observe and evaluate the clinical efficacy of needling'cognitive rehabilitation group points'combined with Donepezil in the treatment of patients with mild post-stroke cognitive impairment(PSCI)of Kidney-essence deficiency syndrome,and to analyze the effects of this therapy on the cognitive level and living ability of the patients with mild PSCI.Methods:62 patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 31 cases in each group.Both groups were given secondary prevention medication and routine rehabilitation training after stroke.The control group was treated with Donepezil,on which basis,the treatment group was also treated with needling'cognitive rehabilitation group points'.After 4 weeks of the treatment,the scores of MMSE scale,MoCA scale and ADL scale,as well as the TCM syndrome integral were observed before and after the treatment in the two groups.The clinical efficacy was compared between the two groups.Results:After the treatment,the total effective rate of the treatment group was 90.32%(28/31),which was significantly higher than 66.67%(20/30)of the control group(P<0.05).The scores of MMSE,MoCA and ADL,as well as the TCM syndrome integral were all significantly improved after the treatment in the two groups(P<0.05);of which the improvements in the treatment group were more significant(P<0.05).Conclusion:Both needling'cognitive rehabilitation group points'combined with Donepezil and single application of Donepezil have obvious clinical curative effect in the treatment of mild PSCI of Kidney-essence deficiency,and the clinical curative effect of the former is more significant than that of the latter.Needling'cognitive rehabilitation group points'has obvious therapeutic advantage in improving Kidney-essence deficiency syndrome,when combined with Donepezil is superior to western monotherapy in terms of improving the cognitive ability and the daily living ability of the patients,which can help patients to improve their cognitive level.