文献类型：期刊文献

英文题名：Effects of gestational diabetes mellitus on the intestinal microbiota of the offspring

作者：Zhang, Ling[1];Tan, Xiao[1];Guo, Zhiru[2];Liang, Lixia[1];Yi, Bin[1];Liu, Xuhui[2];Li, Fei[2];Wang, Yunyun[1];Wang, Yanxia[1]

第一作者：Zhang, Ling

通信作者：Wang, YY[1];Wang, YX[1]

机构：[1]Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China.

年份：2025

卷号：15

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：;Scopus(收录号：2-s2.0-105021811091);WOS:【SCI-EXPANDED(收录号:WOS:001616558200050)】；

基金：This work was supported by Gansu Provincial Science and Technology Project, 24JRRA938 (Yanxia Wang), General Project of Clinical Medical Research of National Center for Clinical Medical Research on Child Health and Diseases, NCRCCHD-2022-GP-17(Yanxia Wang). We gratefully acknowledge all of the participants that contributed to this study.

语种：英文

外文关键词：Gestational diabetes mellitus; Intestinal microbiota; Offspring; Neonatal; Sequencing

摘要：Gestational diabetes mellitus (GDM) significantly impacts maternal and neonatal health, yet its influence on the neonatal intestinal microbiota remains poorly characterized. This study investigated the effects of maternal GDM on offspring microbiota by analyzing meconium samples from newborns of GDM-affected mothers (n = 16) and healthy controls (n = 16). Microbiome analysis revealed distinct composition alterations in the intestinal microbiota of GDM-exposed neonates. Significant differences in microbial abundance were observed between groups: at the phylum level, the GDM group exhibited a significant increase in Bacteroidetes but significant reductions in Actinobacteria and Proteobacteria. At the genus level, opportunistic pathogens including Bacteroides and Escherichia-Shigella were significantly enriched in the GDM group. These findings demonstrate that maternal GDM perturbs the initial colonization of the neonatal intestinal microbiota. Interventions targeting maternal glycemic control during gestation may mitigate offspring microbiota dysbiosis and its potential clinical implications.