文献类型：期刊文献

中文题名：中药调控Wnt/β-catenin信号通路防治胃癌研究进展

英文题名：Advances in the study of traditional Chinese medicine regulating the Wnt/β-catenin signaling pathway for the prevention and treatment of gastric cancer

作者：康莉[1];毛成丹[1];刘鹏鹏[1];袁学玲[1];舒劲[2]

第一作者：康莉

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学第一附属医院,兰州730050

第一机构：甘肃中医药大学

年份：2026

卷号：43

期号：2

起止页码：262

中文期刊名：天津中医药

外文期刊名：Tianjin Journal of Traditional Chinese Medicine

基金：国家自然科学基金项目(82060860);甘肃省教育厅优秀研究生“创新之星”项目(2025CXZX-926)。

语种：中文

中文关键词：Wnt/β-连环蛋白;信号通路;胃癌;中医药;综述

外文关键词：Wnt/β-catenin;signal pathway;gastric cancer;traditional Chinese medicine;review

摘要：胃癌作为全球第5大常见恶性肿瘤,在中国形势尤为严峻。传统治疗方案如手术和放化疗存在局限性,晚期患者5年生存率不足30%,因此,寻求更为高效、安全的治疗策略成为肿瘤医学领域亟待解决的关键问题。近年研究发现,Wnt/β-连环蛋白(β-catenin)信号通路的异常激活与胃癌细胞增殖、转移等恶性行为直接相关。中医药在抗胃癌治疗中展现出独特优势,通过多途径、多机制、多通路协同作用,有效预防术后复发转移,减轻放化疗的不良反应,提高患者的生活质量,成为抗胃癌综合治疗体系中的关键步骤。诸多研究成果表明,萜类、多酚类、黄酮类、生物碱类、多糖复合物、菲醌类等中药活性成分,以及参芪抑瘤方、加味小陷胸汤、补正活血汤、四君子汤、摩罗丹等经典中药复方对Wnt/β-catenin信号通路展现出显著的调控效能,主要通过调节胃癌细胞自噬、抑制胃癌细胞凋亡、影响胃癌上皮间质转化、促进胃癌细胞耐药、驱动胃癌细胞周期全方位影响胃癌的发展和转归,成为抗胃癌研究的关键靶点。全面梳理并总结了近5年中医药抗胃癌的相关研究,聚焦于中医药调控Wnt/β-catenin信号通路治疗胃癌的作用机制,旨在为临床抗胃癌新药研发提供新思路与参考依据。
Gastric cancer,as the fifth most common malignant tumor globally,presents an especially severe challenge in China.Traditional treatment approaches such as surgery and chemoradiotherapy have limitations,with the five-year survival rate for advanced patients remaining below 30%.Consequently,the pursuit of more effective and safer treatment strategies has become a critical issue urgently needing resolution in the field of oncology medicine.Recent studies have revealed that aberrant activation of the Wnt/β-catenin signaling pathway is directly associated with malignant behaviors in gastric cancer cells,including proliferation and metastasis.Traditional Chinese medicine(TCM)demonstrates unique advantages in anti-gastric cancer treatment.Through synergistic actions on multiple pathways,mechanisms,and signaling routes,it effectively prevents postoperative recurrence and metastasis,mitigates the adverse effects of chemoradiotherapy,and improves patients’quality of life,becoming a crucial step in the comprehensive treatment system for gastric cancer.Numerous research findings indicate that TCM active ingredients,such as terpenoids,polyphenols,flavonoids,alkaloids,polysaccharide complexes,and phenanthraquinones,alongside classic TCM formulas like Shenqi Yiliu Formula,Jiawei Xiaoxianxiong Decoction,Buzheng Huoxue Decoction,Sijunzi Decoction,and Moluodan,exhibit significant regulatory effects on the Wnt/β-catenin signaling pathway.They primarily influence the development and progression of gastric cancer by modulating gastric cancer cell autophagy,inhibiting apoptosis,affecting epithelial-mesenchymal transition,regulating drug resistance,and driving the cell cycle,thereby emerging as key targets in anti-gastric cancer research.This article comprehensively reviews and summarizes relevant research on TCM in combating gastric cancer over the past five years,focusing on the mechanisms by which TCM regulates the Wnt/β-catenin signaling pathway to treat gastric cancer.The aim is to offer new perspectives and reference for the clinical development of novel anti-gastric cancer drugs.