文献类型：期刊文献

中文题名：肠道菌群在高血压合并骨质疏松症中的作用

英文题名：Role of intestinal flora in hypertension complicated with osteoporosis

作者：司美龙[1];金华[1];刘敏科[2];刘双芳[1];凌必时[1];祁尚文[1];马雪莉[3]

第一作者：司美龙

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃中医药大学附属医院神经介入科,甘肃兰州730020;[3]甘肃中医药大学附属医院肾病科,甘肃兰州730020

第一机构：甘肃中医药大学中医临床学院

年份：2024

卷号：40

期号：3

起止页码：449

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金资助项目(82160886,81860832);甘肃省自然科学基金资助项目(20JR10RA315);甘肃省自然科学基金资助项目(22JR5RA579);甘肃中医药大学中医学一级学科“岐黄英才”导师专项基金资助项目(ZYXKBD-202203);甘肃省级重点人才基金资助项目(甘组通字[2023]20号)。

语种：中文

中文关键词：高血压;骨质疏松症;肠道菌群

外文关键词：hypertension;osteoporosis;intestinal flora

摘要：高血压和骨质疏松症(OP)是中老年人群常见疾病,近年来两者共病患者逐渐增多。由于该病起病隐匿,病至后期则易引起骨折及心脑肾的严重并发症,不仅严重损害患者生活质量,而且增加了临床治疗难度,因此,加强对此病的研究尤为必要。肠道菌群紊乱会导致OP的发生,而高血压患者肠道菌群明显失调。本文认为肠道菌群可能是高血压合并OP的关键影响因素,肠道菌群失调会导致短链脂肪酸代谢失衡、免疫炎症反应和交感神经活性增强,从而致使骨稳态失衡并促进OP的发生,由此提出调节肠道菌群可能是干预高血压合并OP的新途径。
Hypertension and osteoporosis(OP) are common diseases in middle-aged and elderly people,and the number of patients with both diseases has gradually increased in recent years.Because the onset of the disease is hidden,it is easy to cause fractures and serious complications of heart,brain and kidney in the later stage,which not only seriously damages the quality of life of patients,but also increases the difficulty of clinical treatment.Therefore,it is particularly necessary to strengthen the research on this disease.More and more studies have found that the disorder of intestinal flora will lead to the occurrence of OP,while the intestinal flora of patients with hypertension is obviously out of balance.Therefore,this paper thinks that intestinal flora may be the key influencing factor of hypertension complicated with OP,and the imbalance of intestinal flora will lead to the imbalance of short-chain fatty acid metabolism,immune inflammatory reaction and increased sympathetic nerve activity,thus causing the imbalance of bone homeostasis and promoting the occurrence of OP.Therefore,it is suggested that regulating intestinal flora may be a new way to intervene hypertension complicated with OP.