文献类型：期刊文献

英文题名：MicroRNA-21 as a diagnostic and prognostic biomarker of lung cancer: a systematic review and

作者：Wang, Wei[1];Li, Xinyao[2];Liu, Chengfei[2];Zhang, Xin[3];Wu, Ying[3];Diao, Mingxin[2];Tan, Siyu[2];Huang, Shubin[2];Cheng, Yin[4];You, Tao[3,5]

第一作者：Wang, Wei

通信作者：You, T[1];You, T[2]

机构：[1]China Med Univ, Dept Cardiac Surg, Hosp 1, Shenyang, Liaoning, Peoples R China;[2]Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China;[4]Anhui Med Univ, Clin Med Coll 1, Hefei, Anhui, Peoples R China;[5]Gansu Prov Hosp, Dept Cardiovasc Surg, Lanzhou, Gansu, Peoples R China

第一机构：China Med Univ, Dept Cardiac Surg, Hosp 1, Shenyang, Liaoning, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Cardiovasc Surg, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：42

期号：5

外文期刊名：BIOSCIENCE REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000798983600001)】；

语种：英文

摘要：Background: The relationship between microRNA-21 (miRNA-21) and pathogenesis of lung cancer is a considerable focus of research interest. However, to our knowledge, no in-depth meta-analyses based on existing evidence to ascertain the value of miRNA-21 in diagnosis and clinical prognosis of lung cancer have been documented. Methods: We comprehensively searched all the literature pertaining to ???miRNA-21??? and ???lung cancer??? from four databases from the period of inception of each database until May 2020. Using specific inclusion and exclusion criteria, the literature for inclusion was identified and the necessary data extracted. Results: In total, 46 articles were included in the meta-analysis, among which 31 focused on diagnostic value and 15 on prognostic value. Combined sensitivity (SEN) of miRNA-21 in diagnosis of lung cancer was 0.77 (95% confidence interval (CI): 0.72???0.81), specificity (SPE) was 0.86 (95% CI: 0.80???0.90), diagnostic odds ratio (DOR) was (95% CI: 12???33), and area under the SROC curve (AUC) was 0.87 (95% CI: 0.84???0.90). No significant correlations were observed between abnormal expression of miRNA-21 and gender, smoking habits, pathological type and clinical stage of lung cancer (P>0.05). In terms of overall survival pression of miRNA-21 as an influencing factor for lung cancer. MiRNA-21 was confirmed as an independent risk factor for poor prognosis in multivariate analysis (HR = 1.65, 95% CI: Conclusion: MiRNA-21 has potential clinical value in the diagnosis and prognosis of lung cancer and may serve as an effective diagnostic marker and therapeutic target in the future.