文献类型：期刊文献

中文题名：银纳米粒子的细胞毒性及其诱导的自噬在抗肿瘤中作用机制的研究进展

英文题名：Progress in research on cytotoxicity of silver nanomaterials and induced autophagy

作者：常钰玲[1];牛亚倩(综述)[1];刘芳[1];陈彻(审校)[1]

第一作者：常钰玲

机构：[1]甘肃中医药大学临床医学院,甘肃兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2021

卷号：34

期号：5

起止页码：623

中文期刊名：中国生物制品学杂志

外文期刊名：Chinese Journal of Biologicals

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD_E2021_2022】；

基金：国家自然科学基金(81460456)。

语种：中文

中文关键词：银纳米粒子;细胞毒性;自噬;肿瘤

外文关键词：Silver nanomaterials;Cytotoxicity;Autophagy;Tumor

摘要：纳米材料(nanomaterials)是指在三维空间中至少有一维处于纳米尺寸(0.1~100 nm)或由其作为基本单元构成的材料。银纳米粒子(silver nanoparticles,AgNPs)是重要的纳米材料之一,在纳米科学和纳米技术中发挥着重要作用,特别是在纳米医学领域,包括癌症诊断和治疗中的潜在应用。AgNPs可产生细胞毒作用,特异性靶向肿瘤细胞,具有作为抗肿瘤剂的应用潜力。但AgNPs可激活肿瘤细胞自噬,导致自噬体-溶酶体融合,形成自噬通量缺陷,可能对肿瘤形成保护作用,影响其对肿瘤的细胞毒作用。本文就AgNPs的细胞毒性及其诱导的自噬在抗肿瘤中作用机制的研究进展作一综述。
Nanomaterials refer to materials that have at least one dimension in the nanometer size(0. 1 ~ 100 nm) or are composed of basic units in a three-dimensional space. Silver nanoparticles(AgNPs) are one of the important nanomaterials,which play an important role in nanoscience and nanotechnology,especially in the field of nanomedicine,including potential applications in the diagnosis and treatment of cancers. AgNPs can produce cytotoxicity by targeting tumor cells specifically,therefore has a good application potential as anti-tumor reagent. However,AgNPs can activate tumor cell autophagy,cause autophagosome-lysosome fusion and result in the defect in autophagy flux,which may form a protection and impact the cytotoxicity to tumors. Therefore,this article reviews the mechanism of cytotoxicity of AgNPs and the anti-tumor mechanism of autophagy induced by AgNPs.