文献类型：期刊文献

英文题名：Electrochemical sensors based on graphene/silver sulfide nanocomposites for the indirect detection of mercury sulfide in the Tibetan medicine "Zuo Tai"

作者：Kang, Rongfeng[1];Bai, Xiaoping[2,3];Zhou, Delai[1];Tang, Cong[2,3];Wang, Xin[4];Xi, Jiayu[1];Shao, Shijun[2,3];Dong, Shuqing[2,3];Yang, Fude[1]

第一作者：Kang, Rongfeng

通信作者：Yang, FD[1];Dong, SQ[2];Dong, SQ[3]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China;[2]Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[3]Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China;[4]Northwest Minzu Univ, Sch Chem Engn, Lanzhou 730030, Gansu, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[3]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2026

卷号：271

外文期刊名：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

收录：;Scopus(收录号：2-s2.0-105024734959);WOS:【SCI-EXPANDED(收录号:WOS:001643799500001)】；

基金：This research was supported by the following projects: Key Laboratory of Quality Control for Chinese Materia Medica and Formulas (2024GSMPA-KL/5) ; National Key R & D Program (2024YFC3505603) ; Gansu Provincial Drug Administration Scientific Research Project (2025GSMPA072) ; Gansu Provincial Key Talent Project (2025RCXM069) ; Gansu Provincial Higher Education Industry Support Project (2021CYZC-40) ; Gansu Provincial Key Research Project for Social Development (23YFFA0069) ; Gansu Provincial Academy of Traditional Chinese Medicine Open Project (zyzx-2023-10) ; Gansu Provincial Basic Research Innovation Team Project (23JRRA570) .

语种：英文

外文关键词：Tibetan medicine "Zuo Tai"; HgS; Electrochemical sensors; G/Ag2S electrodes

摘要：Mercury sulfide (HgS) is one of the primary constituents of the Tibetan medicine "Zuo Tai," and its content directly impacts the drug's efficacy and safety. Therefore, developing rapid, direct, and highly sensitive detection methods is of significant importance. In this study, a novel electrochemical sensor based on graphene/silver sulfide (G/Ag2S) nanocomposites was developed for the rapid detection of HgS in Tibetan medicine "Zuo Tai." The G/Ag2S nanocomposite was prepared using the hydrothermal synthesis method. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) analysis indicated that the G/Ag2S nanocomposite enhanced the electrochemical signal response and improved the electrochemical activity of the glassy carbon electrode (GCE) after modification. Under optimized conditions, linear detection of HgS was achieved using differential pulse voltammetry (DPV). The DPV oxidation peak current decreased with increasing HgS concentration due to its adsorption onto the G/Ag2S-modified electrode, which altered the redox properties. The detection range of this analytical method was 0.1-10 mg/L, with a detection limit of 0.0194 mg/L. Further studies revealed that the modified electrode prepared in this paper exhibited excellent selectivity toward HgS. When detecting the HgS content in the "Zuo Tai" sample, the sensor demonstrated high sensitivity, with an average HgS content of 54.38 % in the sample and a relative standard deviation (RSD) of 1.07 %, consistent with the results reported in the literature. This analytical method provides a rapid and reliable quality control method for traditional medicines containing HgS.