文献类型：期刊文献

中文题名：基于玄府-脑络与神经血管单元的相关性分析脑小血管病的病机治法

英文题名：Correlative Analysis of the Pathogenesis and Treatment Methods of Cerebral Small Vessel Disease Based on the Relevance between Xuanfu-Naoluo (Xuanfu and Cerebral Collaterals) and the Neurovascular Unit

作者：包璇[1];金华[1];司美龙[1];张泽祥[1];刘杰[1];杜婕[1];雍芸[1]

第一作者：包璇

机构：[1]甘肃中医药大学中医临床学院,兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2026

卷号：28

期号：2

起止页码：523

中文期刊名：世界科学技术-中医药现代化

外文期刊名：Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金委员会地区基金项目(82160886):基于“肝与大肠相通”理论探讨镇肝熄风汤通过“肠道菌群―胆汁酸”途径干预高血压的机制研究,负责人:金华;甘肃省省级科技计划项目(23JRRA1524):基于“肠-肝-脑”轴研究胆汁酸核受体FXR介导高血压发病的分子机制及镇肝熄风汤的影响,负责人:金华;甘肃省优秀研究生“创新之星”项目(2026CXZX-949):高血压合并脑小血管病患者中医证素、胃肠道症状特征及其与SII、MHR、RDW的相关性研究,负责人:包璇。

语种：中文

中文关键词：玄府;脑络;神经血管单元;脑小血管病;病机治法

外文关键词：Xuanfu;Brain collaterals;Neurovascular unit;Cerebral small vessel disease;Pathogenesis and treatment principles

摘要：旨在从玄府-脑络与神经血管单元(Neurovascular unit,NVU)相关性分析脑小血管病(Cerebral small vessel disease,CSVD)的病机治法。现有研究证实,NVU稳态失衡构成CSVD的核心病理特征,其涉及神经递质调控异常、免疫应答失调、炎症级联激活、氧化应激失衡及其相互作用,较为复杂。玄府-脑络和NVU分别是传统医学和现代医学理论中的微观结构,两者具有极大相似性。本文从结构特性、生理功能进行相关性分析,发现“玄府闭阻,脑络失养”与NVU失稳态具有共性内涵,进而从玄府-脑络理论探讨CSVD的病机治法。CSVD病位在脑,病变在玄府,发病过程分为三个阶段,早期玄府失司,气络郁阻,中期虚实夹杂,郁虚并存,后期肾虚髓减,脑络失养。在治疗中当以调畅玄府,祛邪通络、补肾填精,开玄荣络为原则。本文通过将玄府-脑络与NVU相类比,在看似独立的发病机制中寻找相同致病环节,以期为CSVD等难治性疾病提供安全有效的中西医结合治疗方案。
This article aims to analyze the pathogenesis and treatment principles of cerebral small vessel disease(CSVD)from the perspective of the correlation between the Xuanfu-brain collaterals theory and the neurovascular unit(NVU).Existing studies have shown that the imbalance of NVU homeostasis constituted the core pathological feature of CSVD,which involved abnormal regulation of neurotransmitters,disordered immune response,activation of inflammatory cascades,imbalance of oxidative stress,and their interactions,thus rendering the pathological mechanism of CSVD relatively complex.Xuanfu-brain collaterals and NVU are microscopic structures in traditional Chinese medicine and modern medical theories respectively,and they share great similarities.Therefore,this article conducts a correlation analysis from the aspects of structural characteristics and physiological functions,and holds that“Xuanfu obstruction and insufficient nourishment of brain collaterals”and NVU homeostasis imbalance have common connotations.Furthermore,it explores the pathogenesis and treatment principles of CSVD from the theory of Xuanfu-brain collaterals,and argues that the disease location of CSVD is in the brain,and the lesion is in Xuanfu.The pathogenesis process is divided into three stages:in the early stage,Xuanfu loses its normal function and Qi collaterals are stagnated;in the middle stage,there is a mixture of deficiency and excess,with both stagnation and deficiency;in the late stage,kidney deficiency leads to marrow reduction and insufficient nourishment of brain collaterals.In treatment,the principles should be to regulate and smooth Xuanfu,eliminate pathogenic factors and dredge collaterals,tonify the kidney and replenish essence,as well as open Xuanfu and nourish collaterals.To provide safe and effective integrated traditional Chinese and Western medicine treatment schemes for refractory diseases such as CSVD,the same pathogenic links were sought in the seemingly independent pathogenesis by comparing Xuanfu-brain collaterals with NVU.