文献类型：期刊文献

英文题名：Isolation, Identification, and Activity Evaluation of Chemical Constituents from Soil Fungus Fusarium avenaceum SF-1502 and Endophytic Fungus Fusarium proliferatum AF-04

作者：Jiang, Chun-Xiao[1,4];Li, Jie[1];Zhang, Jun-Min[2];Jin, Xiao-Jie[3];Yu, Bo[1];Fang, Jian-Guo[1];Wu, Quan-Xiang[1]

第一作者：Jiang, Chun-Xiao

通信作者：Wu, QX[1]

机构：[1]Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China;[4]Taizhou Univ, Sch Adv Study, Taizhou 318000, Peoples R China

第一机构：Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：67

期号：7

起止页码：1839

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000459641900008)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Nos. 21672087 and 21202075).

语种：英文

外文关键词：Fusarium avenaceum SF-1502; Fusarium proliferatum AF-04; naphthoisoxazole amide; alkaloid; sesquiterpenoid; 1,4-naphthoquinone; depsipeptide; antibacterial activity

摘要：Fusarium, a large genus of filamentous fungi, is widely distributed in soil and plants. Fusarium is a prolific source of novel chemical constituents with various bioactivities. In search for antibiotics from soil and endophytic fungi, the secondary metabolites of Fusarium avenaceum SF-1502 and Fusarium proliferatum AF-04 were investigated. An alkaloid (1), a depsipeptide (6), and five sesquiterpenoids (7-11) were isolated from the extracts of the soil fungus F. avenaceum SF-1502. Three alkaloids (2-4), a depsipeptide (5), three sesquiterpenoids (9, 11, and 12), a sesterterpene (13), and four 1,4-naphthoquinones (14-17) were also separated from the extract of the green Chinese onion derived fungus F. proliferatum AF-04. Fusaravenin (1) represents the first example of a natural naphthoisoxazole-type zwitter-ionic alkaloid, a naphthoisoxazole formic acid connected with a morpholino carbon skeleton. Cyclonerotriol B (7) is a new cyclonerane sesquiterpene. Another new sesquiterpene, 3 beta-hydroxy-beta-acorenol (12), possesses an acorane framework. The known compounds 9 and 11 were found from both fungi. The structures of the new compounds were determined via extensive HR-ESI-MS and comparison between experimental and calculated NMR results. The biological properties of 1-5 and 7-17 were evaluated against eight anthropogenic bacteria, while 1 and 7-11 were also screened for inhibitory effects against four plant pathogen bacteria. The known compounds 8, 9, and 14-17 showed potent antibacterial activities toward some of the tested anthropogenic bacteria.