文献类型：期刊文献

中文题名：中药靶向NLRP3炎症小体治疗骨质疏松症中的研究进展

英文题名：Research progress in traditional Chinese medicine targeting NLRP3 inflammasome for the treatment of osteoporosis

作者：张良童[1];程渊[1];谢兴文[1,2];张人伟[1];张有良[1];陈欣[1,2]

第一作者：张良童

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃中医药大学附属医院,老年骨科,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2025

卷号：41

期号：17

起止页码：2539

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(82160911;82374491);甘肃省拔尖领军人才基金资助项目(省委人才小组发[2021]2号);第三批省科技计划基金资助项目(23JRRA1226);甘肃省陇原青年创新创业人才(团队)基金资助项目(甘组通字[2023]20号);甘肃省高校产业支撑计划基金资助项目(2023CYZC-57);兰州市第二批科技计划基金资助项目(2024-2-26);甘肃省中医药科研立项课题基金资助项目(GZKZ-2024-9)。

语种：中文

中文关键词：中药;骨质疏松;核苷酸结合寡聚化结构域样受体蛋白3;胱天冬酶-1;白细胞介素1β;白细胞介素18

外文关键词：traditional Chinese medicine;osteoporosis;nucleotide-binding oligomerization domain-like receptor protein3;caspase-1;interleukin-1β;interleukin-18

摘要：骨质疏松症(OP)是一种常见于50岁以上人群的全身性慢性代谢性骨病,极易引发骨折等并发症,严重影响患者的健康与生活质量。核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体由NLRP3受体、凋亡相关斑点样蛋白(ASC)和半胱天冬酶-1前体(pro-caspase-1)组成。在衰老或雌激素缺乏所诱导的慢性炎症微环境下,该炎症小体被激活,通过调节胱天冬酶-1(caspase-1)依赖的促炎细胞因子白细胞介素1β(IL-1β)和白细胞介素18(IL-18)的成熟及分泌,介导炎症反应、诱导细胞焦亡;这一过程不仅加速了骨吸收,还抑制了骨形成,最终增加了OP的风险。中药可以通过靶向NLRP3炎症小体发挥治疗OP的作用。本文全面综述了NLRP3炎症小体的结构、激活过程,以及中药通过靶向NLRP3炎症小体治疗OP的复杂作用机制,旨在为OP的靶向治疗提供新思路,同时为探寻治疗OP的理想靶点提供参考。
Osteoporosis(OP)is a common systemic chronic metabolic bone disease that primarily affects individuals over the age of 50.It is highly prone to causing complications such as fractures,which severely impair patients'health and quality of life.The nucleotide-binding oligomerization domain like receptor protein 3(NLRP3)inflammasome is composed of the NLRP3 receptor,apoptosis-associated speck-like protein containing a CARD(ASC),and pro-caspase-1.In the chronic inflammatory microenvironment induced by aging or estrogen deficiency,this inflammasome is activated.It mediates inflammatory responses and induces pyroptosis by regulating the maturation and secretion of caspase-1-dependent proinflammatory cytokines,namely interleukin?1β(IL-1β)and interleukin-18(IL-18).This process not only accelerates bone resorption but also inhibits bone formation,ultimately increasing the risk of OP.Traditional Chinese medicine(TCM)can exert therapeutic effects on OP by targeting the NLRP3 inflammasome.This article comprehensively reviews the structure and activation process of the NLRP3 inflammasome,as well as the complex mechanisms through which TCM treats OP by targeting the NLRP3 inflammasome.The aim is to provide new insights for the targeted therapy of OP and serve as a reference for identifying ideal therapeutic targets for OP.