文献类型：期刊文献

中文题名：胡蓝降糖缓释片对糖尿病大鼠糖脂代谢的影响

英文题名：Effects of Hulan Hypoglycemic Sustained Release Tablets on Glucose and Lipid Metabolism in Diabetic Rats

作者：杨建英[1];靳素琴[1];王晓莉[2];朱建坤[3]

第一作者：杨建英

机构：[1]甘肃省疾病预防控制中心,兰州730000;[2]甘肃中医学院附属医院,兰州730000;[3]甘肃中医学院,兰州730000

第一机构：甘肃省疾病预防控制中心,兰州730000

年份：2014

卷号：31

期号：1

起止页码：27

中文期刊名：实验动物科学

外文期刊名：Laboratory Animal Science

收录：CSTPCD

基金：甘肃省中医药管理局科研项目(GZK-2012-59)

语种：中文

中文关键词：胡蓝降糖缓释片;糖尿病;大鼠;糖脂代谢

外文关键词：Hulan hypoglycemic sustained-release tablets;diabetic mellitus; rats; glucose and lipid metabolism

摘要：目的观察胡蓝降糖缓释片(TGE)对糖尿病大鼠模型糖脂代谢状态和胰岛功能的影响。方法对SPF级雄性Wistar大鼠予以链脲佐菌素(STZ)40 mg/kg腹腔注射,建立糖尿病动物模型。设立正常对照组、糖尿病组、二甲双胍对照组及胡蓝降糖缓释片干预组(TGE组)。二甲双胍对照组及TGE组分别予以盐酸二甲双胍和胡蓝降糖缓释片灌胃;4周后杀鼠留取血样检测空腹血糖(FBG)、甘油三酯(TG)、胆固醇(CHO)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)。采用放射免疫法(RIA)检测血清空腹胰岛素(FINS)水平。结果 TGE显著降低糖尿病大鼠血糖,差异显著(P<0.05);TGE提高糖尿病大鼠FINS水平,差异显著(P<0.05)。结论胡蓝降糖缓释片对糖尿病大鼠模型糖脂代谢紊乱及胰岛功能有一定的调节作用。
Objective To investigate the effects of Hulan hypoglycemic sustained-release tablets（TGE） on glucose and lipid metabolism and islet function in diabetic animal model. Method The animal models of diabetes mellitus was established by intraperitoneal injection of streptoztocin （STZ）40 mg/kg. The rats were divided randomly into four groups ： normal control group, diabetic group, western medicine group （repaglinide） and Hulan hypoglycemie sustained-release tablets group. After different administration for 4 weeks, the rats were killed and blood sample was collected for fasting blood glucose （FBG） , Triglyceride （TG） , total cholesterol （ CHO ） , high-density lipoprotein cholesterol （ HDL-C ） and low density lipoprotein cholesterol （ LDL-C ） and fasting insulins （FINS）. Result Compared with other,the pancreas was fixed for intervention groups,TGE group had lower blood glucose（P 〈 0.05 ）. Compared with normal control group, other group shown lower FINS （ P 〈 0.05 ）. Compared with diabetic group, western medicine group no difference for FINS（P 〉 0.05 ） , but the difference of FINS was observed between TGE group and diabetic control group （P 〈 0.05 ）. Conclusion Hulan hypoglycemic sustained-release tablets have a modulatory role in glucose and lipid metabolism and function of pancreatic islet in diabetic animal model.