文献类型：期刊文献

中文题名：HIF-1α和HIF-2α在胃癌中的表达及意义

英文题名：Expression and significance of HIF-1α and HIF-2α in human gastric cancer

作者：李能莲[1];李光明[2];骆亚莉[1];张立[1];舍雅莉[1];王雅莉[1];胡树名[1]

第一作者：李能莲

机构：[1]甘肃中医学院病理教研室;[2]兰州大学第二医院消化科,甘肃兰州730000

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

年份：2010

卷号：30

期号：6

起止页码：619

中文期刊名：基础医学与临床

外文期刊名：Basic and Clinical Medicine

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：低氧诱导因子-1α;低氧诱导因子-2α;胃癌

外文关键词：hypoxia inducible factor-1α; hypoxia inducible factor-2α; gastric cancer

摘要：目的探讨胃癌中低氧诱导因子HIF-1α和HIF-2α的表达及其临床意义。方法用免疫组化SP法检测组织中HIF-1α、HIF-2α及VEGF的表达;用Western blot法检测组织中HIF-1α、HIF-2α的表达。结果胃癌中HIF-1α、HIF-2α和VEGF的阳性表达率分别为61.5%、36.5%和61.5%,均显著高于正常对照组的11.1%、0和0;HIF-1α表达与VEGF及胃癌的淋巴结转移密切相关。胃癌组织中HIF-1α和HIF-2α蛋白的表达显著高于癌旁正常胃黏膜组织。结论低氧诱导因子的表达可能在胃癌的发生、发展中具有重要作用。
Objective To explore the expression and significance of the hypoxia inducible factor（HIF-1α and HIF-2α） in human gastric cancer.Methods SP immunohistochemical method was used to detect the expression of HIF-1α,HIF-2α and VEGF.Western blot method was used to measure the expression of HIF-1α and HIF-2α in the tissue samples.Results Compared with the normal tissue,gastric cancer had significantly higher expression rate of HIF-1α（61.5% vs 11.1%）,HIF-2α（36.5% vs 0）and VEGF（61.5% vs 0）.The expression of HIF-1α was significantly and correlated with lymph node metastasis and VEGF expression.Expression of HIF-1α and HIF-2α in gastric cancer tissues was significantly higher than that of adjacent non-cancerous gastric mucosa.ConclusionThe expression of HIF-1α and HIF-2 α may play important roles in the development and progression of ganstric cancer.