文献类型：期刊文献

中文题名：中药莪术拮抗致突变作用的初步研究

英文题名：Preliminary study on antagonistic effects or Rhizoma Zedoariae on mutagenic action

作者：李应东[1];李啸红[1];王毓美[2]

第一作者：李应东

机构：[1]甘肃中医学院,兰州730000;[2]兰州大学生物系

第一机构：甘肃中医药大学

年份：1999

卷号：7

期号：1

起止页码：22

中文期刊名：中国优生与遗传杂志

外文期刊名：Chinese Journal of Birth Health & Heredity

收录：CSTPCD

基金：国家中医药管理局青年课题!910061

语种：中文

中文关键词：莪术;致突变性;抑制率;中药药理学

外文关键词：Rhizoma Zedoariae, Mutagenicity, Antimutagenicty. Inhibiting rate.

摘要：用鼠伤寒沙门氏菌/大鼠肝微粒体酶突变实验次突变抑制实验、观察莪术的致突变性及其抑制2-氨基芴（2－AF）致突变物作用。结果：莪术醇提物剂量在0．15－30．0g（原药重）／皿的范围内、均未见有致突变性；莪术醇提物具有明显抑制2-AF诱导鼠伤寒沙门氏菌回复突变作用，并具有明显的剂量效应关系。提示：莪术对化学物的致突变性有一定的抑制作用。
The study was designed to investigate the mutagenicity of Rhizoma Zedoariae (RZ) and the antagonistic effects of RZ on fluorenamin (2) (2-AF) induced the mutagenesis. with the Salmonella/microsome mutagenicity test and mutagenicity inhibiting test. The results showed that RZ itself is not genotoxic, that 2-AF induced the Salmonella mutagensis might be inhibited by RZ with a dose dependent relationship. These suggested that RZ is not mutagenic and inhibitation to the chemical mutagen induced the mutagenitity.