文献类型：期刊文献

英文题名：Biomimetic chitosan-graft-polypeptides for improved adhesion in tissue and metal

作者：Lu, Dedai[1];Wang, Hongsen[1];Wang, Xiangya[1];Li, Yunfei[1];Guo, Hongyun[2];Sun, Shaobo[3];Zhao, Xiaolong[1];Yang, Zhiwang[1];Lei, Ziqiang[1]

第一作者：Lu, Dedai

通信作者：Lu, DD[1]

机构：[1]Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Ecoenvironm Related Polymer Mat, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China;[2]Gansu Prov Canc Hosp, Inst Gansu Med Sci Res, Lanzhou 730050, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China

第一机构：Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Ecoenvironm Related Polymer Mat, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China

通信机构：[1]corresponding author), Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Ecoenvironm Related Polymer Mat, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China.

年份：2019

卷号：215

起止页码：20

外文期刊名：CARBOHYDRATE POLYMERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000464112700003)】；

基金：This work was supported in part by the National Natural Science Foundation of China (Nos. 51103118, 21865029), Innovation Team Project of NWNU (NWNU-LKQN-16-02) and Longyuan Youth Innovation and Entrepreneurial Talents Project. We also thank Key Laboratory of Eco-environment-related Polymer Materials Ministry of Education, Key Lab of Polymer Materials of Gansu Province, for financial support.

语种：英文

外文关键词：Chitosan; Polypeptide; Biomimetic adhesive; Biocompatible; Surgical adhesive

摘要：Inspired by the mussel foot protein and chitosan-based macromolecular adhesives, a series of chitosan-graft-polypeptides were synthesized by ring-opening polymerization of three N-carboxyanhydrides (NCAs) -3,4-di-hydroxyphenylalanine-N-carboxyanhydride (DOPA-NCA), cysteine-NCA (Cys-NCA) and arginine-NCA (Arg-NCA) - using partial-NH2-protected chitosan as an initiator. These copolymers demonstrated good biodegradability and low cytotoxicity. The results of lap-shear adhesion test showed that the maximum lap-shear adhesion strength on the porcine skin and aluminum sheet were 195.97 +/- 21.1 kPa and 3080 +/- 320 kPa, respectively, and the maximum tensile adhesion strength on bone was 642.70 +/- 61.1 kPa. The rat experiment in vivo showed that these copolymers exhibited good hemostatic performance and can promote the healing of skin wound and bone fracture. It is expected that thesecopolymeric adhesives will have broad applications in hemostasis and soft tissue adhesions.