文献类型：期刊文献

英文题名：Roles and mechanisms of circular RNA in respiratory system cancers

作者：Yang, Nan[1];Jiao, Mengwen[2];Zhang, Yuewen[2];Mo, Shaokang[3];Wang, Ling[3];Liang, Jianqing[1]

第一作者：杨楠

通信作者：Liang, JQ[1]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China;[3]940th Hosp Joint Logist Support Force Chinese Peop, Dept Obstet & Gynecol, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：14

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85200001542);WOS:【SCI-EXPANDED(收录号:WOS:001278081000001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. Double First-Class initiative projects of Gansu Province of China (GSSYLXM-05).

语种：英文

外文关键词：circRNA; respiratory system; non-small cell lung cancer; nasopharyngeal cancer; Laryngeal squamous cell carcinoma

摘要：Circular RNAs (circRNAs) constitute a class of endogenous non-coding RNAs (ncRNAs) that lack a 5'-ended cap and 3'-ended poly (A) tail and form a closed ring structure with covalent bonds. Due to its special structure, circRNA is resistant to Exonuclease R (RNaseR), making its distribution in the cytoplasm quite rich. Advanced high-throughput sequencing and bioinformatics methods have revealed that circRNA is highly conserved, stable, and disease- and tissue-specific. Furthermore, increasing research has confirmed that circRNA, as a driver or suppressor, regulates cancer onset and progression by modulating a series of pathophysiological mechanisms. As a result, circRNA has emerged as a clinical biomarker and therapeutic intervention target. This article reviews the biological functions and regulatory mechanisms of circRNA in the context of respiratory cancer onset and progression.