文献类型：期刊文献

中文题名：当归多糖对运动性疲劳模型大鼠运动耐力的影响及抗氧化作用

英文题名：Effects of Angelica sinensis polysaccharide(ASP)on exercise endurance and antioxidant capacity in rats with exercise-induced fatigue

作者：何吉福[1];黄彩云[1];董峰[1];陈沛[1]

第一作者：何吉福

机构：[1]甘肃中医药大学体育健康学院,甘肃兰州70101

第一机构：甘肃中医药大学体育健康学院

年份：2026

卷号：43

期号：1

起止页码：9

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

基金：甘肃省自然科学基金项目(1606RJZA197)。

语种：中文

中文关键词：运动性疲劳;当归多糖;超氧化物歧化酶;谷胱甘肽过氧化物酶;丙二醛;肝糖原;游泳时间;大鼠;实验研究

外文关键词：exercise-induced fatigue;Angelica sinensis polysaccharide(ASP);superoxide dismutase(SOD);glutathione peroxidase(GSH-Px);malondialdehyde(MDA);hepatic glycogen;swimming time;rats;experimental study

摘要：目的观察当归多糖(ASP)对超负荷运动所致机体疲劳的保护作用及对运动耐力的影响。方法将50只雄性SD大鼠采用随机数字表法分为空白组,模型组,ASP低(200 mg/kg)、中(400 mg/kg)、高(800 mg/kg)剂量组,每组10只。除空白组外,其余各组均进行5%体质量负重游泳训练,连续训练15 d,建立负重游泳疲劳模型;每日训练前1 h,ASP各剂量组灌胃相应剂量ASP溶液,空白组与模型组给予等体积生理盐水。检测大鼠血清及心脏、肝脏组织中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平,以及肝脏组织中肝糖原含量。结果与模型组比较,ASP高剂量组负重游泳时间,ASP低、中、高剂量组力竭游泳时间明显延长,差异均有统计学意义(P<0.01);与模型组比较,ASP高剂量组心脏,ASP低剂量组肝脏,ASP低、中、高剂量组血清SOD水平明显升高,ASP低剂量组肝脏,ASP低、中、高剂量组血清GSH-Px水平明显升高,ASP低、中、高剂量组心脏,ASP中、高剂量组肝脏,ASP低、高剂量组血清MDA水平明显降低,差异均有统计学意义(P<0.05或P<0.01);与模型组比较,ASP中、高剂量组肝脏组织中肝糖原含量明显升高,差异有统计学意义(P<0.01)。结论ASP具有减轻超负荷运动所致机体疲劳及提高运动耐力的作用,可以用于高强度运动群体的保健品开发。
Objective To observe the protective effects of Angelica sinensis polysaccharide(ASP)on fatigue caused by overload exercise and its impact on exercise endurance.Methods 50 male SD rats were randomly divided into a blank group,model group,and low-dose(200mg/kg),medium-dose(400 mg/kg),and high-dose(800 mg/kg)ASP groups(n=10 per group).Except for the blank group,all other groups underwent 5%body weight-loaded swimming training for 15 consecutive days to establish weight-loaded swimming fatigue model.One hour before daily training,ASP groups received intragastric administration of corresponding doses,while the blank and model groups received an equal volume of physiological saline.After the experiment,levels of malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)in serum,heart,and liver tissues,as well as hepatic glycogen content in liver tissues,were measured.Results Compared with the model group,the high-dose ASP group showed significantly prolonged weighted swimming time(P<0.01),and the low-,medium-,and high-dose ASP groups exhibited significantly extended exhaustive swimming time(P<0.01).SOD levels increased significantly in the high-dose ASP group(heart),low-dose ASP group(liver),and serum of low-,medium-,and high-dose ASP groups(P<0.05 or P<0.01).GSH-Px levels increased markedly in the low-dose ASP group(liver)and serum of all ASP groups(P<0.05 or P<0.01).MDA levels decreased significantly in the heart of low-,medium-,and high-dose ASP groups,liver of medium-and high-dose ASP groups,and serum of low-and high-dose ASP groups(P<0.05 or P<0.01).Hepatic glycogen content rose significantly in the medium-and high-dose ASP groups(P<0.01).Conclusion ASP alleviates overload exercise-induced fatigue and enhances exercise endurance,demonstrating potential for developing health products for high-intensity exercise populations.