文献类型：期刊文献

英文题名：Research Progress of Traditional Chinese Medicine in Treatment of Myocardial fibrosis

作者：Ren, Chunzhen[1];Liu, Kai[1];Zhao, Xinke[2];Guo, Huan[1];Luo, Yali[1];Chang, Juan[1,3];Gao, Xiang[1,2];Lv, Xinfang[1,2];Zhi, Xiaodong[1,2];Wu, Xue[1,4];Jiang, Hugang[1];Chen, Qilin[1];Li, Yingdong[1]

第一作者：任春贞

通信作者：Li, YD[1]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[3]Gansu Prov Peoples Hosp, Lanzhou, Peoples R China;[4]Lanzhou Univ, Second Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85133326995);WOS:【SCI-EXPANDED(收录号:WOS:000814510400001)】；

基金：This is work was supported by the 2021 Jiaoyu Jiebang Guashuai Project (no. 2021jyjbgs-03), 2022 Gansu Province Longyuan Youth Innovation and Entrepreneurship Talent Project, 2022 Gansu Province outstanding graduate student "Innovation Star" project and National Natural Science Foundation of China (nos, 81860786 and 81873132).

语种：英文

外文关键词：traditional Chinese medicine; myocardial fibrosis; research progress; mechanism; prevention and treatment

摘要：Effective drugs for the treatment of myocardial fibrosis (MF) are lacking. Traditional Chinese medicine (TCM) has garnered increasing attention in recent years for the prevention and treatment of myocardial fibrosis. This Article describes the pathogenesis of myocardial fibrosis from the modern medicine, along with the research progress. Reports suggest that Chinese medicine may play a role in ameliorating myocardial fibrosis through different regulatory mechanisms such as reduction of inflammatory reaction and oxidative stress, inhibition of cardiac fibroblast activation, reduction in extracellular matrix, renin-angiotensin-aldosterone system regulation, transforming growth Factor-beta 1 (TGF-beta 1) expression downregulation, TGF-beta 1/Smad signalling pathway regulation, and microRNA expression regulation. Therefore, traditional Chinese medicine serves as a valuable source of candidate drugs for exploration of the mechanism of occurrence and development, along with clinical prevention and treatment of MF.