文献类型：期刊文献

英文题名：m6A: a novel strategy for osteoporosis treatment

作者：Yan, Chunlu[1];Xiao, Xiaolong[2];Yang, Fan[2];Shi, Yangyang[3];Wan, Qiao[2];Zhang, Yan[4];An, Fangyu[5]

第一作者：颜春鲁

通信作者：Zhang, Y[1];An, FY[2]

机构：[1]Gansu Univ Chinese Med, Dunhuang Med Acad, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Trad Chinese & Werstern Med, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China;[4]Lanzhou Modern Vocat Coll, Sch Hlth & Hlth, Lanzhou, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Lanzhou Modern Vocat Coll, Sch Hlth & Hlth, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：13

外文期刊名：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

收录：;Scopus(收录号：2-s2.0-105016762264);WOS:【SCI-EXPANDED(收录号:WOS:001575364900001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was finically supported by the National Natural Science Foundation of China (Grant number: 82060872), Gansu Natural Science Foundation (Grant number: 24JRRA1018 and 24JRRA1026), the Scientific Research Program of Gansu Chinese Medicine Bure (Grant number: GZKG-2024-88), the Research and Reform Project of Graduate Education and Teaching at Gansu University of Chinese Medicine (Grant number: 2023-15), Graduate Innovation and Entrepreneurship Fund Project of Gansu University of Chinese Medicine (Grant number: 2025CXCY-006); Graduate Student "Innovation Star" Project of Gansu Province (Grant number: 2025CXZX-938).

语种：英文

外文关键词：osteoporosis; M6A; mesenchymal stem cell; osteoblast; osteoclast

摘要：Osteoporosis (OP) is a systemic metabolic disease characterised by increased bone fragility, with bone loss being the primary cause of its onset and progression. Regulating the dynamic balance between osteoblast (OB) formation and osteoclast-mediated bone resorption is crucial for preventing bone loss in OP. N6-methyladenosine (m6A), the most abundant and common RNA modification, is regulated by various proteins, including m6A methyltransferases, demethylases, and binding proteins. m6A methylation plays a key role in bone metabolism in OP, influencing the osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs), the osteogenic differentiation and bone formation capacity of OBs, as well as osteoclastic differentiation and resorptive activity. However, the specific molecular mechanisms through which m6A methylation regulates bone metabolism in OP remain incompletely understood. In this review, we comprehensively discuss the structure and function of m6A and summarise the roles of m6A methyltransferases, demethylases, and binding proteins. We also examine the regulatory mechanisms of m6A in MSCs, OBs, and osteoclasts, and discuss associated targeted therapies. This overview of the research on m6A is expected to highlight valuable insights and the translational potential for developing treatment strategies for OP.