文献类型：期刊文献

英文题名：Identification of Codonopsis Radix from different sources by integrating high-performance liquid chromatography fingerprinting with chemometric approaches and Lobetyolin determination

作者：Liu, Xuxia[1];Liu, Xiaoling[1];Wang, Xin[1];Chen, Zhengjun[1];Nan, Danhui[1];Luo, Wenrong[2];Yang, Fude[1,3]

第一作者：刘旭旭;刘晓霞

通信作者：Yang, FD[1]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Dept Identificat & Qual Evaluat Chinese Med, Lanzhou, Peoples R China;[2]Gansu Prov Hosp Chinese Med, Dept Pharm, Lanzhou, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Sch Pharm, 35 Dingxi East Rd, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Sch Pharm, 35 Dingxi East Rd, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

外文期刊名：SEPARATION SCIENCE PLUS

收录：WOS:【ESCI(收录号:WOS:001207435200001)】；

基金：The authors are thankful to the Gansu University of Chinese Medicine for providing laboratory and device support.

语种：英文

外文关键词：Codonopsis Radix; identification; storage time; sulfur fumigation; variety

摘要：Codonopsis Radix (CR) is often used as both a medicine and a food ingredient. However, identifying CR can be difficult due to various factors such as variety, sulfur fumigation, and storage time. Consequently, a comprehensive strategy based on fingerprinting and chemometric approaches was developed to distinguish different CRs. First, the fingerprints of CR were acquired by high-performance liquid chromatography (HPLC). Secondly, various chemical pattern recognition methods were employed to identify CR. Additionally, 14 and 16 major compounds were identified as marker compounds to differentiate between different varieties and sulfur-fumigated samples, respectively. Furthermore, the amount of Lobetyolin present in different samples was determined, showing that the content of Lobetyolin varied significantly across the samples. Codonopsis pilosula Nannf. var. modesta (Nannf.) L.T.Shen had the highest content of Lobetyolin, followed by Codonopsis tangshen Oliv., and Codonopsis pilosula (Franch.) Nannf. In addition, the content of Lobetyolin was highest when it was non-sulfur-fumigated and stored for 0 years. Conclusively, HPLC fingerprint in conjunction with chemical pattern recognition and component content determination, can be employed to differentiate different varieties and sulfur-fumigated CR. Additionally, it is a reliable, comprehensive, simple, and rapid method for the identification of CR.