文献类型：期刊文献

中文题名：阿司匹林联合氯吡格雷对脑梗死患者血小板聚集功能和预后的影响

英文题名：Effect of aspirin combined with clopidogrel on platelet function and prognosis in patients with cerebral infarction

作者：刘敏科[1];韩艳萍[1];金华[2];王琼[1];杨禄萍[1]

第一作者：刘敏科

机构：[1]甘肃中医药大学附属医院神经内科,甘肃兰州730020;[2]甘肃中医药大学中医临床医学院,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2015

卷号：34

期号：12

起止页码：883

中文期刊名：甘肃医药

外文期刊名：Gansu Medical Journal

语种：中文

中文关键词：阿司匹林;氯吡格雷;血小板聚集;预后

外文关键词：aspirin; clopidogrel; platelet function; prognosis

摘要：目的:评估阿司匹林联合氯吡格雷对脑梗死患者血小板聚集功能及预后的影响。方法:选取我院从2013年1月到2015年11月入院治疗的69例脑梗死患者做为研究对象。按照入院顺序随机分为观察组34例与对照组35例,对照组患者应用阿司匹林治疗,观察组患者应用阿司匹林联合氯吡格雷治疗。对比两组患者治疗后血小板聚集功能及预后的影响。结果:观察组患者治疗后的血小板聚集功能抑制效果显著优于对照组患者,差异具统计学意义(P<0.05)。观察组患者治疗后的神经功能评分改善情况显著优于对照组患者,观察组患者的复发率显著低于对照组,差异具统计学意义(P<0.05)。结论:临床应用阿司匹林联合氯吡格雷治疗脑梗死患者,可有效拮抗血小板活性,改善神经功能,有利于患者预后恢复与降低复发,值得临床广泛推广应用。
Objective： To evaluate the effect of aspirin combined with clopidogrel on platelet function and prognosis in patients with cerebral infarction. Methods： 69 patients with cerebral infarction treated by our hospital from Jan 2013 to Nov 2015 were selected as the research objects. According to the order of admission, 34 patients were randomly divided into observation group and 35 patients in control group in which the control group were treated with aspirin, and the observation group were treated with aspirin plus clopidogrel. After treatment of two groups, the platelet function and prognosis of patients were compared. Results： The inhibition effect of platelet function after treatment in the observation group was significantly better than that in the control group（P0.05）. The score of neurological function after treatment in the observation group was significantly better than that in the control group（P〈0.05）. The recurrence rate of the observation group was significantly lower than that of the control group in which the difference was statistically significant（P〈0.05）.Conclusion： The clinical application of aspirin combined with clopidogrel in the treatment for cerebral infarction patients, can effectively reduce the platelet activity, improve neurological function.The treatment is conducive to the recovery of patients with cerebral infarction and reduce patients＇ recurrence, which is worthy of extensive application.