文献类型：期刊文献

中文题名：生骨再造丸联合利塞膦酸钠治疗肾虚血瘀型骨质疏松症的临床观察

英文题名：Clinical Observation of Shenggu Zaizao(生骨再造)Pills Combined with Risedronate Sodium Tablets in the Treatment of Osteoporosis of Shenxu Xueyu(肾虚血瘀)Syndrome

作者：赵建栋[1];刘贝[1];郭成龙[2];张晓刚[2];毕煦昆[1];魏玉娇[2];李纪书[1];刘凯雯[1];刘志寰[1]

第一作者：赵建栋

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院,兰州730000

第一机构：甘肃中医药大学

年份：2025

卷号：41

期号：7

起止页码：67

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：;北大核心:【北大核心2023】；

基金：张晓刚全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号);甘肃省中管局项目(编号:GZKP-2022-20);甘肃中医药大学附属医院项目(编号:gzfy-2022-06);兰州市科技计划项目(编号:2023-2-7)。

语种：中文

中文关键词：生骨再造丸;骨质疏松症;疗效观察;骨密度;Ⅰ型前胶原氨基末端肽;Ⅰ型胶原交联C-末端肽

外文关键词：Shenggu Zaizao(生骨再造)Pills;Osteoporosis;Efficacy observation;Bone density;PINP;CTX

摘要：目的:观察生骨再造丸对骨质疏松症患者的临床疗效。方法:选取自2021年10月-2022年12月期间,在甘肃中医药大学附属医院门诊就诊的骨质疏松患者120例。按随机数字表法分为3组(n=40)。基础组服用维D钙咀嚼片+骨化三醇软胶囊;对照组服用维D钙咀嚼片+骨化三醇软胶囊+利塞膦酸钠片;观察组服用维D钙咀嚼片+骨化三醇软胶囊+生骨再造丸;观察各组患者治疗前与治疗后2 w、治疗后3月时VAS、BMD、骨代谢指标(PINP、CTX)及疗效评价。结果:对照组降低VAS评分、CTX,增加BMD、PINP优于基础组,观察组降低VAS评分、CTX水平,增加BMD、PINP水平优于基础组及对照组(P<0.05);对照组治疗后的总有效率高于基础组,观察组治疗后的总有效率高于基础组及对照组(P<0.05)。结论:生骨再造丸通过增加患者骨密度,影响骨代谢水平对骨质疏松症有显著的治疗作用,且在治疗期间未发现明显不良反应,安全性较高,值得临床进一步探讨与使用。
Objective:To observe the clinical efficacy of Shenggu Zaizao(生骨再造)Pills in patients with osteoporosis.Methods:A total of 120 patients with osteoporosis,who visited the outpatient clinic of the Affiliated Hospital of Gansu University of Chinese Medicine from October 2021 to December 2022,were selected.They were divided into three groups(n=40):the basic group(vitamin D calcium chewable tablets+calcitriol soft capsules),the control group(vitamin D calcium chewable tablets+calcitriol soft capsules+risedronate sodium tablets),and the observation group(vitamin D calcium chewable tablets+calcitriol soft capsules+Shenggu Zaizao Pills).The visual analogue scale(VAS),bone mineral density(BMD),bone metabolism markers[procollagen type Ⅰ N-terminal propeptide(PINP),C-terminal telopeptide(CTX)],and the efficacy were evaluated in each group before treatment,two weeks after treatment,and three months after treatment.Results:The control group had a greater reduction in VAS scores than the basic group,and the observation group demonstrated a greater reduction than both basic and control groups(P<0.05).In terms of BMD improvement,the control group was superior to the basic group,and the observation group had a greater improvement than both basic and control groups(P<0.05).The control group exhibited increased PINP bone metabolism compared with the basic group,and the observation group also showed a greater increase than the basic group(P<0.05).The control group achieved a more significant reduction in CTX than the basic group,and there was a decreased level in the observation group compared with the basic and control groups(P<0.05).The total effective rate after treatment was higher in the control group than in the basic group,and higher in the observation group than in both basic and control groups(P<0.05).Conclusion:Shenggu Zaizao Pills exerted a significant effect on osteoporosis by increasing BMD and influencing bone metabolism.No obvious adverse reactions were found during treatment,indicating high safety.The prescription was worthy of further clinical exploration and application.