文献类型：期刊文献

英文题名：Meta analysis of the diagnostic value of circulating miRNA in benign and malignant pulmonary nodules

作者：Hong, Ziqiang[1,2];Cui, Baiqiang[1,2];Bai, Xiangdou[1,2];Li, Hongchao[1,2];Cheng, Tao[1,2];Sheng, Yannan[1];Lu, Yingjie[1];Wu, Xusheng[1,2];Jin, Dacheng[2];Zhao, Jing[3];Gou, Yunjiu[2]

第一作者：Hong, Ziqiang

通信作者：Gou, YJ[1];Zhao, J[2]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Thorac Surg, Lanzhou, Peoples R China;[3]Lanzhou First Peoples Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Thorac Surg, Lanzhou, Peoples R China;[2]corresponding author), Lanzhou First Peoples Hosp, Lanzhou, Peoples R China.

年份：2023

卷号：21

期号：1

外文期刊名：WORLD JOURNAL OF SURGICAL ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85170351086);WOS:【SCI-EXPANDED(收录号:WOS:001061549600001)】；

基金：Not applicable.

语种：英文

外文关键词：Pulmonary nodules; Benign and malignant; Circulating miRNA; Diagnosis; Meta-analysis

摘要：Objective A meta-analysis was conducted to assess the impact of miRNAs in circulation on diagnosing benign and malignant pulmonary nodules (BPNs and MPNs). Methods Electronic databases such as Embase, PubMed, Web of Science, and The Cochrane Library were utilized for diagnostic tests of circulating miRNAs to diagnose BPNs and MPNs from the library creation to February 2023. Meta-analysis of the included literature was performed using Stata 16, Meta-Disc 1.4, and Review Manager 5.4 software. This study determined the combined sensitivity, specificity, diagnostic ratio (DOR), positive/negative likelihood ratios (PLR/NLR), as well as value of area under the receiver operating characteristic (ROC) curve. Results This meta-analysis included 14 publications and 17 studies. According to our findings, the pooled sensitivity for miRNA in diagnosing benign and malignant pulmonary nodules was 0.82 [95% CI (0.74, 0.88)], specificity was 0.84 [95% CI (0.79, 0.88)], whereas the DOR was 22.69 [95% CI (13.87, 37.13)], PLR was 5.00 [95% CI (3.87, 6.46)], NLR was 0.22 [95% CI (0.15, 0.32)], and the area under the working characteristic curve (AUC) of the subject was 0.89 [95% CI (0.86, 0.91)]. Conclusion Circulating miRNAs could be used with sensitivity, specificity, DOR, PLR, NLR, and AUC as biomarkers to diagnose pulmonary nodules (PNs). However, more research is needed to determine the optimum miRNA combinations for diagnosing PNs due to the significant heterogeneity on previous studies.