文献类型：期刊文献

中文题名：STAT3在心房纤维化中的研究进展

英文题名：Research progress of STAT3 in atrial fibrosis

作者：汪小刚[1];刘颖[1];苏芳菊[2];蔡晓庆[2]

第一作者：汪小刚

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]中国人民解放军联勤保障部队第九四〇医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2025

卷号：37

期号：5

起止页码：576

中文期刊名：心脏杂志

外文期刊名：Chinese Heart Journal

基金：甘肃省自然科学基金项目(22JR5RA013)。

语种：中文

中文关键词：信号转录和转导激活因子3;心房纤维化;研究进展

外文关键词：signal transducer and activator of transcription 3;atrial fibrosis;research progress

摘要：心房纤维化是指心房肌间质中胶原纤维的异常增生和沉积,导致心房肌细胞外基质的改变。正常情况下,纤维组织占心房组织含量的2%~4%,但在心房纤维化的情况下,胶原纤维组织含量可能超过心房组织的10%。心房纤维化对心脏健康具有严重危害,一方面,它加速了心房颤动的发生和维持,使病情更加复杂;另一方面,心房纤维化导致心房结构改变,增加了心脏病的并发症风险,如心力衰竭、心脏骤停等。因此,研究心房纤维化的发病机制、寻找新的纤维化相关信号通路,对于防治心血管疾病具有重要意义。信号转录和转导激活因子3(STAT3)是一种蛋白质,属于信号转导和激活域家族成员之一。STAT3在细胞信号传导过程中起着重要作用,能够调节多种基因的表达,从而影响细胞的生长、分化、迁移等生物学功能。近年来,研究发现STAT3在心房纤维化的发生和发展中也扮演着重要角色。本文将对STAT3在心房纤维化中的研究进行综述。
Atrial fibrosis refers to the abnormal proliferation and deposition of collagen fibers in the atrial muscle interstitium,resulting in changes in the extracellular matrix of the atrial muscle.Normally,fibrous tissue accounts for 2%-4%of the atrial tissue content,but in the case of atrial fibrosis,the collagen fibrous tissue content may exceed 10%of the atrial tissue.Atrial fibrosis is a serious hazard to heart health.On the one hand,it accelerates the occurrence and maintenance of atrial fibrillation,making the condition more complex,and on the other hand,atrial fibrosis leads to changes in the structure of the atrium,increasing the risk of complications of heart disease,such as heart failure and cardiac arrest,etc.Therefore,it is of great significance to study the pathogenesis of atrial fibrosis and find new fibrosisrelated signaling pathways for the prevention and treatment of cardiovascular diseases.Signal transducer and activator of transcription 3(STAT3)is a protein that belongs to the signal transduction and activation domain family.STAT3 plays an important role in cell signaling and can regulate the expression of a variety of genes,thereby affecting the biological functions of cells such as growth,differentiation and migration.In recent years,studies have found that STAT3 also plays an important role in the occurrence and progression of atrial fibrosis.This article will review the research on the role of STAT3 in atrial fibrosis.