文献类型：期刊文献

中文题名：rs-fMRI在针刺治疗阿尔茨海默病中的中枢机制研究进展

英文题名：Progress in research on central mechanisms of rs-fMRI in acupuncture treatment of Alzheimer's disease

作者：谢雯婷[1];李丽[1];陈玉竹[2];魏玉婷[1];马玲[1];严兴科[1]

第一作者：谢雯婷

机构：[1]甘肃中医药大学针灸推拿学院,兰州730000;[2]青海大学医学院中医系,西宁810016

第一机构：甘肃中医药大学针灸推拿学院

年份：2025

卷号：16

期号：12

起止页码：177

中文期刊名：磁共振成像

外文期刊名：Chinese Journal of Magnetic Resonance Imaging

收录：;北大核心:【北大核心2023】；

基金：甘肃中医药大学2022年研究生一流课程立项项目(编号:甘中医大研发〔2022〕67号);2023年度研究生课程思政示范课项目(编号:甘中医大研发〔2023〕55号);2024年度校级协同创新中心项目(编号:甘中医大科发〔2024〕17号);2025年度甘肃中医药大学研究生“创新创业基金”项目(编号:2025CXCY-031)。

语种：中文

中文关键词：阿尔茨海默病;针刺;静息态功能磁共振成像;磁共振成像;中枢机制

外文关键词：Alzheimer's disease;acupuncture;resting-state functional magnetic resonance imaging;magnetic resonance imaging;central mechanism

摘要：阿尔茨海默病(Alzheimer's disease,AD)是以进行性认知功能减退为主要临床表现的疾病,严重影响患者身心健康和社会发展。针刺是治疗AD的有效方法之一,可显著改善AD症状,延缓病情进展,但其中枢机制尚未完全明确。静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)因无辐射、时间空间分辨率高、显影度高等优势,为深入研究针刺治疗AD的中枢机制提供了可视化手段。本文通过梳理总结rs-fMRI在针刺治疗AD的中枢机制相关研究,阐述了当前研究的局限性并指出了今后研究的方向,发现AD患者存在脑区结构损伤、脑区间功能连接异常、脑网络连接效应减弱等病理表现,针刺可通过减轻海马、颞叶、扣带回、尾状核等脑区结构损伤,改善后扣带回、颞叶、顶叶、额叶等脑区间功能连接异常,增强大尺度脑网络默认模式网络(default mode network,DMN)、额顶控制网络(fronto parietal network,FPN)、中央执行网络(central executive network,CEN)、感觉运动网络(sensorimotor network,SMN)和网络间背侧注意网络(dorsal attention network,DAN)-DMN连接效应以发挥治疗AD的作用,以期为今后针刺治疗AD中枢机制的深入研究与临床方案优化提供更加全面的参考。
Alzheimer's disease(AD)is a disease characterized by progressive cognitive decline as the main clinical manifestation,which seriously affects patients'physical and mental health and social development.Acupuncture is one of the effective methods for treating AD,which can significantly improve AD symptoms and delay disease progression,but its central mechanism has not been fully clarified.Functional magnetic resonance imaging(fMRI)technology,with advantages such as no radiation,high temporal and spatial resolution,and high imaging clarity,provides a visual means for in-depth study of the central mechanism of acupuncture in the treatment of AD.By sorting out and summarizing the studies on the central mechanism of resting-state functional magnetic resonance imaging(rs-fMRI)in acupuncture treatment of AD,elaborates on the limitations of current research and points out the directions for future studies,this paper finds that AD patients have pathological manifestations such as structural damage in brain regions,abnormal functional connections between brain regions,and weakened connection effects of brain networks.Acupuncture can exert its role in treating AD by reducing structural damage in brain regions such as the hippocampus,temporal lobe,cingulate gyrus,and caudate nucleus,improving abnormal functional connections between brain regions such as the posterior cingulate gyrus,temporal lobe,parietal lobe,and frontal lobe,enhancing the connectivity effects of large-scale brain networks,including the default mode network(DMN),fronto-parietal network(FPN),central executive network(CEN),sensorimotor network(SMN),as well as the inter-network connectivity between the dorsal attention network(DAN)and DMN,so as to exert a therapeutic effect on AD,with the aim of providing a more comprehensive reference for the in-depth research on the central mechanism of acupuncture in the treatment of AD and the optimization of clinical protocols in the future.