文献类型：期刊文献

中文题名：非编码RNA在高血压及高血压肾损伤中的研究进展

英文题名：Research progress of non-coding RNA in hypertension and hypertensive renal injury

作者：黎永祥[1];腾政杰[2];李梦瑶[1];寇雨顺[1];何亚丽[1];申进增[1];伊琳[1]

第一作者：黎永祥

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]甘肃中医药大学附属医院心血管内科,甘肃兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2021

卷号：59

期号：10

起止页码：187

中文期刊名：中国现代医生

外文期刊名：China Modern Doctor

基金：国家自然科学基金项目(81760803)。

语种：中文

中文关键词：非编码RNA;高血压;高血压肾损伤;研究进展

外文关键词：Non-coding RNA;Hypertension;Hypertensive kidney injury;Research progress

摘要：高血压肾损伤是临床常见病,也是高血压的严重并发症,随着高血压患者的增加及日趋年轻化,由此导致的肾脏损伤也在与日俱增,高血压肾损伤在全世界范围内发病率呈上升趋势,严重威胁着人类的健康和生存质量。原发性高血压长期控制不佳,特别是由于恶性高血压的控制失调,引起肾脏血流动力学改变,进而导致肾小球硬化、肾小管萎缩、肾间质纤维化,并逐渐出现肾功能不全的临床表现,即为高血压肾损伤。研究发现,非编码RNA在高血压及高血压肾损伤中存在特异性表达并发挥重要作用,为高血压肾损害的机制研究及靶向治疗提供新思路,本文就高血压肾损伤中的非编码RNA的特异性表达、作用机制、作用靶点的研究进展作出如下综述。
Hypertensive kidney injury is a common clinical disease and a serious complication of hypertension.With the increase in the number of hypertensive patients and the decrease in the age of onset,the kidney injury caused by this is also increasing daily.The incidence of hypertensive kidney injury is increasing worldwide,which seriously threatens human health and quality of life.The long-term poor control of essential hypertension,especially the control disorder due to the malignant hypertension,causes renal hemodynamic changes,which in turn leads to clinical manifestations such as glomerular sclerosis,renal tubular atrophy,renal interstitial fibrosis,and gradual occurrence of renal insufficiency,namely hypertensive kidney injury.Studies have found that non-coding RNA has a specific expression and plays an important role in hypertension and hypertensive kidney injury,which provides new ideas for the mechanism research and targeted therapy of hypertensive renal damage.This article summarizes the research progress of specific expression of non-coding RNA,mechanism of action,and targets of action in hypertensive kidney injury.