文献类型：期刊文献

中文题名：单味中药抗肺纤维化效应的规律分析及其Logistic回归模型

英文题名：Analysis of correlation between traditional Chinese medicinal characteristics and anti-pulmonary fibrosis effects and Logistic regression model

作者：陈丽[1];刘永琦[1];李朝霞[2];魏莉莉[1];杨云帆[1]

第一作者：陈丽

机构：[1]甘肃中医学院基础课部,兰州730000;[2]甘肃省第二人民医院感染科,兰州730000

第一机构：甘肃中医药大学

年份：2013

卷号：28

期号：1

起止页码：247

中文期刊名：中华中医药杂志

外文期刊名：China Journal of Traditional Chinese Medicine and Pharmacy

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD_E2013_2014】；

基金：甘肃省教育厅第二批科研项目计划(No.1106B-05);甘肃中医学院中青年基金项目(No.BH2011-0020)~~

语种：中文

中文关键词：中药;抗肺纤维化;Logistic;规律性

外文关键词：Traditional Chinese medicine; Anti-pulmonary fibrosis effects; Logistic; Regularity

摘要：目的:根据已发表有关单味中药抗肺纤维化(PF)效应现代医学研究文献,分析中药特征与抗肺纤维化效应的关系并建立相应的数学模型。方法:收集、筛选1989年以来国内公开发表的《中华人民共和国药典》(2010版)所载单味中药抗肺纤维化研究文献,统计不同功能分类、药性、药味、归经的中药数量和其中具有抗肺纤维化效应的中药味数;用多元判别分析建立回归数学模型。结果:在46味具有抗肺纤维化的中药中,活血化瘀药有8味,归经分类分析归胆经的有6味,与其在药典中所占比例比较差异均有统计学意义(P<0.05)。逐步Logistic回归筛选主要影响因素,结果表明归胆经、膀胱经以及补虚药、活血化瘀药、收涩药均是抗肺纤维化效应的重要影响因素(回归系数>0且P<0.01)。多元判别分析预测结果与原判定结果总符合率为91.0%。结论:中药的传统功能分类、药性、归经与抗肺纤维化效应关系密切,以此为基础建立的数学模型可作为中药抗肺纤维化效应研究及临床用药的参考。
Objective：To create mathematical model and analysis of correlation between Chinese medicinal characteristics and anti-pulmonary fibrosis effects based on literatures.Methods： The numbers of the Chinese medicines with anti-pulmonary fibrosis effects were worked out within the frame work of China Pharmacopeia of 2010 edition,from the literature publicized since 1989.The correlation and mathematical model were figured out between Chinese medicinal characteristics including traditional functional classification,different tastes as well as channel tropism and anti-pulmonary fibrosis activity;and create regression mathematical model by multivariate discriminant analysis.Results： The anti-pulmonary fibrosis effects is related to the xu-invigorating drugs,blood-activating and stasis-resolving herbs,astringent herbs（P0.05）.The coincidence was 91.0% between mathematical computing and original classification.Conclusion： There are correlations between Chinese medicinal characteristics including traditional functional classification,different tastes as well as channel tropism and anti-pulmonary fibrosis effects.The mathematical model based on these results can be used for studing of anti-pulmonary fibrosis effects and clinical treatment.