文献类型：期刊文献

英文题名：Eremophilane Sesquiterpenes With Antichlamydial Activity Isolated From Ligularia macrophylla

作者：Gao, Na[1,2];Li, Guo-Li[1];Zha, Xiang-Tao[1];Yang, Hong-Ying[1];He, Yi-Lin[1];Shen, Tong[1]

第一作者：Gao, Na;高娜

通信作者：He, YL[1];Shen, T[1]

机构：[1]Lanzhou Jiaotong Univ, Res Inst, Sch Chem & Chem Engn, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China

第一机构：Lanzhou Jiaotong Univ, Res Inst, Sch Chem & Chem Engn, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Jiaotong Univ, Res Inst, Sch Chem & Chem Engn, Lanzhou, Peoples R China.

年份：2026

卷号：23

期号：6

外文期刊名：CHEMISTRY & BIODIVERSITY

收录：;Scopus(收录号：2-s2.0-105042181285);WOS:【SCI-EXPANDED(收录号:WOS:001794915400001)】；

基金：Financial support is from the National Natural Science Foundation of China (No. 22467016), Gansu Provincial Agricultural Science and Technology Support Project (No. KJZC-2024-16), and the Talent Innovation and Entrepreneurship Project of Lanzhou (No. 2022-RC-45).

语种：英文

外文关键词：antichlamydial activity; Asteraceae; eremophilane sesquiterpenes; Ligularia macrophylla; natural products

摘要：Three new eremophilane-type sesquiterpenoids (1-3), along with two known eremophilenolides (4-5), were obtained from the whole of Ligularia macrophylla. The structures were determined by spectroscopic analysis and comparison with reported data. Compounds 1-5 were evaluated for their antichlamydial activities by an experimental model employing L929 cells infected with Chlamydia abortus. Compound 3, at a concentration of 100 & micro;M, exhibited activity comparable to that of the positive control tetracycline at a concentration of 20 & micro;g/mL, while showing no cytotoxicity. Preliminary structure-activity relationships for these eremophilenolides are reported.