文献类型：期刊文献

英文题名：The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis

作者：Guo, Yafei[1];Li, Yang[1];Cao, Qiang[1];Ye, Leilei[1];Wang, Junmei[1];Guo, Mei[1,2]

第一作者：Guo, Yafei

通信作者：Guo, M[1];Guo, M[2]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[2]Gansu Prov Coll, Key Lab Chem & Qual Tradit Chinese Med & Tibetan M, Lanzhou, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Coll, Key Lab Chem & Qual Tradit Chinese Med & Tibetan M, Lanzhou, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85134424717);WOS:【SCI-EXPANDED(收录号:WOS:000828225000001)】；

基金：This work was supported by the key Project of Joint Funds of the National Natural Science Foundation of China (U21A20412); the Provincial Natural Science Foundation of Gansu Province, China (21JR7RA558); the Double First-Class key Scientific Research Project of the Department of Education of Gansu Province, China (GSSYLXM-05); the Project of Central Government Guides the Development of Local Science and Technology, Gansu Province, China.

语种：英文

外文关键词：natural polysaccharides; ulcerative colitis; structure; mechanism; gut flora

摘要：Ulcerative colitis (UC) is an inflammatory bowel disease that is persistent and nonspecific. There are several medications available for the treatment of UC. However, conventional UC medications have substantial adverse effects, low clinical effectiveness, and a high recurrence rate. Therefore, it is critical to discover new medicines that are both safe and effective for UC patients. Natural polysaccharides offer a wide range of pharmacological benefits, including anti-inflammatory, anti-virus, anti-tumor, anti-aging, immune enhancement, and gut flora regulation. In the therapy of UC, natural polysaccharides can modulate inflammatory factors, the immune system, and intestinal flora, and preserve the intestinal mucosa. It demonstrates a good curative effect and is of safety to use, thereby being a potential treatment for UC patients. This paper covers the structure, the pharmacological effects on UC, and the mechanisms of natural polysaccharides. Finally, limitations, challenges, and perspectives are discussed. It is hoped that the findings of this publication will inspire more natural polysaccharides research and provide a theoretical foundation for the creation of new UC medications.