文献类型：期刊文献

英文题名：Association between levels of IgG antibodies from vaccines and Omicron symptomatic infection among children and adolescents in China

作者：Chen, Xinying[1,2];Hong, Junbin[3];Deng, Lijun[1,2];Weng, Heng[4];Huang, Teng[1,2];Wang, Li[5];Ou, Aihua[4];Li, Yuxia[6];Yu, Bo[7];Guo, Jianwen[4,8];Yang, Jinghua[1,2]

第一作者：Chen, Xinying

通信作者：Yang, JH[1];Yang, JH[2];Guo, JW[3];Yu, B[4];Guo, JW[5]

机构：[1]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Pediat, Guangzhou, Peoples R China;[2]Guangdong Prov Hosp Chinese Med, Xiaorong Luos Renowned Expert Inheritance Studio, Guangzhou, Peoples R China;[3]Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou, Peoples R China;[4]Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China;[5]2 Peoples Hosp Lanzhou, Dept Lab, Lanzhou, Peoples R China;[6]Gansu Univ Chinese Med, Affiliated Hosp, Dept Pediat, Lanzhou, Peoples R China;[7]2 Peoples Hosp Lanzhou, Dept Surg, Lanzhou, Peoples R China;[8]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Neurol, Guangzhou, Peoples R China

第一机构：Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Pediat, Guangzhou, Peoples R China

通信机构：[1]corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Pediat, Guangzhou, Peoples R China;[2]corresponding author), Guangdong Prov Hosp Chinese Med, Xiaorong Luos Renowned Expert Inheritance Studio, Guangzhou, Peoples R China;[3]corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China;[4]corresponding author), 2 Peoples Hosp Lanzhou, Dept Surg, Lanzhou, Peoples R China;[5]corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Neurol, Guangzhou, Peoples R China.

年份：2023

卷号：10

外文期刊名：FRONTIERS IN MEDICINE

收录：;Scopus(收录号：2-s2.0-85170573940);WOS:【SCI-EXPANDED(收录号:WOS:001064875000001)】；

基金：This study was supported by National Key R&D Programmes (NKPs) of China, aimed at Evidence-based evaluation of Fuzheng Jiedu Fang to block severe transformation of infection with SARS-Cov-2 Delta variant ( No.2022YFC0867400). It was also supported by State Administration of Traditional Chinese Medicine, an urgent project for Chinese Medicine on Novel Coronavirus Pneumonia (Nos. 2022ZYLCYJ07-3 and 2022ZYLCYJ11-2), Guangdong Provincial Administration of Traditional Chinese Medicine (No. 2022ZYYJ04), State Key Laboratory of Dampness Syndrome of Chinese Medicine in the Provincial Cooperation Administration (No. SZ2022XG01), and Xiaorong Luo's Renowned Expert Inheritance Studio (No. 14GG2X02). The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

语种：英文

外文关键词：IgG levels; antibody; SARS-CoV-2; Omicron; symptomatic infection

摘要：BackgroundMeasurements of IgG antibodies to wild-type SARS-CoV-2 antigens can assess vaccine efficacy, but the absolute risk of Omicron symptomatic infection at different IgG levels for children and adolescents remains uncertain, as well as the minimum effective antibody level. We sought to determine the relationship between the tertiles of IgG antibodies to wild-type SARS-CoV-2 antigens and children with symptomatic infection of the pandemic and duration to negative conversion in China for the first time.MethodsA retrospective study was conducted, including 168 participants under 18 years old from the No.2 People's Hospital of Lanzhou, China, diagnosed with Omicron variant BA.2.38 between July 8, 2022, and August 2, 2022. We calculated odds ratios (OR) in univariate and multivariate regression to assess the association of symptomatic infection with the tertiles of IgG, respectively. Kaplan-Meier curves and Cox proportional hazards regression were used to evaluate the relationship between IgG level and negative conversion time.ResultsThe average age of the 168 children included in this study was 7.2 (4.7) years old, 133 (79.2%) were symptomatic patients, and the average negative conversion time was 12.2 (3.5) days. The participants with high IgG levels were less likely to become symptomatic, had a shorter turnaround time, and had higher values of IgM and nucleic acid CT. Compared to those with the lowest tertile of IgG, patients with the highest tertile had a 91% lower risk of developing a symptomatic infection after fully adjusting for confounders (OR = 0.09, 95% CI, 0.02-0.36, p = 0.001). There's no robust relationship between IgG level and negative conversion time in multivariate Cox regression.ConclusionThe risk of developing a symptomatic infection can be predicted independently by tertiles of IgG antibodies to wild-type SARS-CoV-2 antigens. High IgG levels can inhibit viral replication, vastly reduce the risk of symptomatic infections and promote a virus-negative conversion, especially when IgG quantitative detection was & GE;3.44 S/CO, a potential threshold for protection and booster strategy in the future. More data and research are needed in the future to validate the predictive models.