文献类型：期刊文献

中文题名：肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响

英文题名：Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease

作者：孙杰[1];赵鸿亮[1];王俊霞[1];吴立文[1]

第一作者：孙杰

机构：[1]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2007

卷号：13

期号：9

起止页码：37

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD

基金：甘肃省中医管理局(2004-GZK-07)

语种：中文

中文关键词：慢性肺源性心脏病;肺心通;野百合碱;支气管肺泡灌洗液;白介素8;肿瘤坏死因子α

外文关键词：chronic pulmonary heart disease; Feixintong; monocrotaline; bronchoalveolar lavage fluid;interleukin-8 ; tumor necrosis factor-α

摘要：目的:探讨肺心通对慢性肺源性心脏病(CPHD)模型大鼠的治疗效果及作用机理。方法:Wistar大鼠用野百合碱(MCT,60 mg.kg-1)1次腹腔注射复制CPHD大鼠模型,以肺心通混悬液治疗,21 d后,行支气管肺泡灌洗液(BALF)细胞总数及分类计数,测定大鼠血清、肺组织匀浆、肺泡灌洗液(BALF)中白介素8(IL-8)、肿瘤坏死因子α(TNF-α)的含量,肺组织切片在光镜、电镜下观察病理形态改变。结果:经治疗后,肺心通混悬液对上述检测指标的水平有明显抑制作用(P<0.01或P<0.05),在光、电镜下观察对大鼠肺血管内皮细胞的损伤有一定的修复作用。结论:肺心通药物对CPHD大鼠有较好的治疗作用。
Objective：To research the effect and the mechanism of Feixintofig on rat model of chronic pulmonary heart disease （CPHD）. Methods：50 Wistar rats were randomly divided into five groups. Rats were given a single injection of monocrotaline（MCT,60μg/g）to induce the model of CPHD. The Feixintong groups were treated by suspension in 21 days, then total white cell counts and differential counts and interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α）were examined. Lung organism slices were observed with microscope. Results： The examined items of the Feixintong groups were lower than the model groups （P 〈 0.01 or P 〈 0.05）, endotheliocytes were repaired by Feixintong. Conclusions： Feixintong has good efficacy for treatment of rat model of CPHD.