文献类型：期刊文献

中文题名：中医药干预mTOR通路靶向自噬防治糖尿病肾病的研究现状

英文题名：Research status of traditional Chinese medicine intervention in mTOR pathway targeting autophagy for prevention and treatment of diabetic nephropathy

作者：杨世睿[1];周婷婷[1];马超超[1];杨鹏斐[1];牛凡琪[1];杜雪洋[1];闫丰喆[1];王思农[1]

第一作者：杨世睿

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2024

卷号：40

期号：11

起止页码：1675

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：甘肃省教育厅产业支撑计划基金资助项目(2021CYZC-03)。

语种：中文

中文关键词：磷酸肌醇-3-激酶/蛋白激酶B/哺乳动物西罗莫司靶蛋白信号通路;腺苷酸活化蛋白激酶/哺乳动物西罗莫司靶蛋白信号通路;自噬;糖尿病肾病

外文关键词：phosphoinositol 3 kinase/protein kinase B/mammalian rapamycin target pathway;adenosine monophosphate-activated protein kinase/mammalian target of rapamycin signaling pathway;autophagy;diabetic kidney

摘要：糖尿病肾病(DKD)是糖尿病最重要的并发症之一。近年来,国内外研究发现,哺乳动物西罗莫司靶蛋白(mTOR)相关信号通路是参与自噬调节的一个经典通路,可通过靶向自噬途径达到治疗DKD的效果,在防治DKD中发挥着至关重要的作用。本文将主要从中医药干预mTOR相关信号通路靶向自噬防治DKD的作用机制做一综述,以期为临床防治DKD提供新的参考及依据。
Diabetic kidney disease(DKD) is one of the most important complications of diabetes. In recent years, domestic and foreign studies have found that mammalian target protein of rapamycin(mTOR) related signaling pathway is a classic pathway involved in the regulation of autophagy, which can achieve the therapeutic effect of DKD by targeting the autophagy pathway, and plays a crucial role in the prevention and treatment of DKD.In this paper, we reviewed the mechanism of mTOR-related signaling pathway targeted autophagy in the prevention and treatment of DKD,in order to provide a new reference and basis for clinical prevention and treatment of DKD.