文献类型：期刊文献

中文题名：基于H型血管探讨中药治疗骨质疏松症作用机制的研究进展

英文题名：Research progress in exploring mechanism of Chinese materia medica in treating osteoporosis based on H?type blood vessels

作者：刘德孙[1];樊佳煊[1];拦玉鑫[1];曹林忠[1,2];马小成[1];张维[1];崔瑞[1]

第一作者：刘德孙

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730030

第一机构：甘肃中医药大学

年份：2025

卷号：59

期号：6

起止页码：94

中文期刊名：上海中医药杂志

外文期刊名：Shanghai Journal of Traditional Chinese Medicine

基金：国家自然科学基金项目(82160915);兰州市科技局项目(2022-3-23)。

语种：中文

中文关键词：骨质疏松症;H型血管;信号通路;作用机制;中药;研究进展

外文关键词：osteoporosis;H-type blood vessels;signal pathway;mechanism of action;Chinese materia medica;research progress

摘要：综述基于H型血管探讨中药治疗骨质疏松症作用机制的研究进展。研究发现,中药对H型血管的调控主要集中在血管中缺氧诱导因子-1α(HIF-1α)/血管内皮生长因子(VEGF)、切口通路(Notch)、血小板衍生生长因子-BB(PDGF-BB)、刺猬通路(Hedgehog)等关键通路,通过调节其上下游信号以及相关靶基因、靶蛋白的表达,促进骨组织血管再生和骨细胞成骨分化,刺激血管生成与成骨耦合,从而改善骨骼内部结构、稳定骨代谢、减少骨流失、增加骨密度、实现骨质疏松症的有效防治。
This paper reviews the research progress on the mechanism of Chinese materia medica treatment of osteoporosis based on H-type vessels.Studies have found that the regulation of Chinese materia medica on H-type blood vessels mainly focuses on key pathways such as hypoxia-inducing factor-1α(HIF-1α)/vascular endothelial growth factor(VEGF),Notch,platelet-derived growth factor-BB(PDGF-BB)and Hedgehog.By regulating the expression of its upstream and downstream signals as well as related target genes and target proteins,it can promote bone tissue angiogenesis and osteoblast differentiation,stimulate the coupling of angiogenesis and osteoblast,thereby improving the internal structure of bone,stabilizing bone metabolism,reducing bone loss,increasing bone density,and realizing effective prevention and treatment of osteoporosis.