文献类型：期刊文献

英文题名：EMT-related gene risk model establishment for prognosis and drug treatment efficiency prediction in hepatocellular carcinoma

作者：Gao, Xiaqing[1];Yang, Chunting[1,2,3,4];Li, Hailong[1,2,3,4,5];Shao, Lihua[1,2,5];Wang, Meng[1,2,3,4];Su, Rong[1]

第一作者：Gao, Xiaqing

通信作者：Li, HL[1];Li, HL[2];Li, HL[3];Li, HL[4];Li, HL[5]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Geriatr, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Key Lab Tradit Chinese Herbs & Prescript Innovat &, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Gansu Prov Tradit Chinese Med New Prod Innovat Eng, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat, Minist Educ, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Geriatr, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Key Lab Tradit Chinese Herbs & Prescript Innovat &, Lanzhou 730000, Gansu, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Gansu Prov Tradit Chinese Med New Prod Innovat Eng, Lanzhou 730000, Gansu, Peoples R China;[5]corresponding author), Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat, Minist Educ, Lanzhou 730000, Gansu, Peoples R China.|[107359c91a78c5fd2e803]甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）;[10735]甘肃中医药大学;[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;

年份：2023

卷号：13

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001681482000001)】；

基金：The study was supported by the grant, including the guiding planning project of Lanzhou Science and Technology Bureau (NO: 2022-5-113)and the project of Open Fund of Key Laboratory of Dunhuang Medicine and Transformation, Ministry of Education (DHYX-18-18).

语种：英文

摘要：This study was designed to evaluate the prognosis and pharmacological therapy sensitivity of epithelial mesenchymal transition-related genes (EMTRGs) that obtained from the EMTome database in hepatocellular carcinoma (HCC) using bioinformatical method. The expression status of EMTRGs were also investigated using the clinical information of HCC patients supported by TCGA database and the ICGC database to establish the TCGA cohort as the training set and the ICGC cohort as the validation set. Analyze the EMTRGs between HCC tissue and liver tissue in the TCGA cohort in the order of univariate COX regression, LASSO regression, and multivariate COX regression, and construct a risk model for EMTRGs. In addition, enrichment pathways, gene mutation status, immune infiltration, and response to drugs were also analyzed in the high-risk and low-risk groups of the TCGA cohort, and the protein expression status of EMTRGs was verified. The results showed a total of 286 differentially expressed EMTRGs in the TCGA cohort, and EZH2, S100A9, TNFRSF11B, SPINK5, and CCL21 were used for modeling. The TCGA cohort was found to have a worse outcome in the high-risk group of HCC patients, and the ICGC cohort confirmed this finding. In addition, EMTRGs risk score was shown to be an independent prognostic factor in both cohorts by univariate and multivariate COX regression. The results of GSEA analysis showed that most of the enriched pathways in the high-risk group were associated with tumor, and the pathways enriched in the low-risk group were mainly associated with metabolism. Patients in various risk groups had varying immunological conditions, and the high-risk group might benefit more from targeted treatments. To sum up, the EMTRGs risk model was developed to forecast the prognosis for HCC patients, and the model might be useful in assisting in the choice of treatment drugs for HCC patients.