文献类型：期刊文献

英文题名：Cardiac Function Transition in Patients with Chronic Kidney Disease Undergoing Maintenance Hemodialysis in a High-Altitude Multi-Ethnic Region: A Comparative Study Between Yi and Non-Yi Ethnic Groups

作者：Zhang, Jingjing[1,2,3];Li, Zhaoyu[4];Xiao, Xueliang[5];Liu, Xuesong[6];Qiao, Qian[1,2,3];Cheng, Lu[1,2,3];Sha, Jun[5];Yang, Yufei[7];Zhang, Wangzheqi[8];Zhang, Haoling[9];Ye, Xuerui[1,2,3]

第一作者：Zhang, Jingjing

通信作者：Ye, XR[1];Ye, XR[2];Ye, XR[3];Zhang, HL[4]

机构：[1]Kunming Med Univ, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Chinese Acad Med Sci, Kunming 650000, Peoples R China;[2]Yunnan Prov Cardiovasc Clin Med Ctr, Kunming 650000, Peoples R China;[3]Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming 650000, Peoples R China;[4]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Peoples R China;[5]Ninglang Yi Autonomous Cty Peoples Hosp, Internal Med Dept 2, Ninglang 674300, Peoples R China;[6]Gansu Univ Chinese Med, Basic Med Coll, Lanzhou 730000, Peoples R China;[7]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[8]Naval Med Univ, Sch Anesthesiol, Shanghai, Peoples R China;[9]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Kepala Batas 13200, Penang, Malaysia

第一机构：Kunming Med Univ, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Chinese Acad Med Sci, Kunming 650000, Peoples R China

通信机构：[1]corresponding author), Kunming Med Univ, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Chinese Acad Med Sci, Kunming 650000, Peoples R China;[2]corresponding author), Yunnan Prov Cardiovasc Clin Med Ctr, Kunming 650000, Peoples R China;[3]corresponding author), Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming 650000, Peoples R China;[4]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Kepala Batas 13200, Penang, Malaysia.

年份：2026

卷号：19

外文期刊名：JOURNAL OF INFLAMMATION RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001761353200001)】；

基金：Yunnan Fundamental Research Kunming Medical University Projects, China, No.202401AY070001-164; and Yunnan Provincial Department of Science and Technology Science and Technology Plan Project-Major Science and Technology Special Projects, China, No. 202405AJ310003.

语种：英文

外文关键词：chronic kidney disease; maintenance hemodialysis; high altitude; ethnic differences; cardiac function; pulmonary artery systolic pressure

摘要：Background: Cardiovascular disease is the leading cause of mortality in patients with chronic kidney disease (CKD), particularly among those undergoing maintenance hemodialysis (MHD). High-altitude exposure may further aggravate cardiovascular stress through chronic hypoxia. However, longitudinal data in multi-ethnic high-altitude dialysis populations remain limited.
Objective: To evaluate changes in cardiac function in CKD stage 5/end-stage renal disease patients receiving MHD at high altitude and to compare findings between Yi and non-Yi ethnic groups.
Methods: This retrospective study included 161 patients (103 Yi, 58 non-Yi) undergoing MHD in Ninglang Yi Autonomous County (mean altitude > 2800 m). Clinical characteristics, laboratory parameters-including homocysteine (HCY)-and echocardiographic indices were assessed at baseline, 3 months, and 12 months. Longitudinal trends and ethnic differences were analyzed.
Results: In the overall cohort, pulmonary artery systolic pressure (PASP) increased significantly over time (P=0.049), while the E/A ratio declined, indicating progressive diastolic impairment. Left ventricular ejection fraction (LVEF) remained stable At 12 months, Yi patients had higher HCY levels (P=0.034), lower albumin (P=0.010) and apolipoprotein A levels (P=0.044), and a higher incidence of aortic regurgitation (AR) (P=0.012). Baseline E/A ratio was higher in Yi patients (P=0.032).
Conclusion: CKD patients undergoing MHD at high altitude exhibit dynamic changes in cardiac function, predominantly involving pulmonary pressure and diastolic parameters. Ethnic differences in selected biochemical and echocardiographic indices suggest the need for tailored cardiovascular monitoring in high-altitude multi-ethnic dialysis populations.