文献类型：期刊文献

英文题名：CONCISE SYNTHESIS OF (±)-CEPHALOTAXINE

作者：Zhan, Jian[1,2,3];Ding, Huili[1];Fan, Yuxue[1];Chen, Hui[1,2];Dai, Hongxia[1,2];Jing, Ming[1,2]

第一作者：Zhan, Jian

通信作者：Zhan, J[1];Dai, HX[1];Zhan, J[2];Dai, HX[2];Zhan, J[3]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou 730000, Peoples R China;[3]Key Lab Chem & Qual TCM Coll Gansu Prov, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou 730000, Peoples R China;[3]corresponding author), Key Lab Chem & Qual TCM Coll Gansu Prov, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：106

期号：1

起止页码：166

外文期刊名：HETEROCYCLES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001026632700001)】；

基金：ACKNOWLEDGEMENTS This work was supported by the National Natural Science Foundation of China (21562001) , the Natural Science Foundation of Gansu Province (22JR5RA586) and the Educational Science and Technology Innovation Program of Gansu Province (2021 CYZC-13) .

语种：英文

摘要：The construction of 1-azaspiro[4.4]nonane framework was achieved via the key Stevens rearrangement reaction of the Weinreb amide. And the subsequent steps mediated by the carbonyl of Weinreb amide led to the concise formal synthesis of (& PLUSMN;)-cephalotaxine. Further development and application of asymmetric Stevens rearrangement of the Weinreb amide are underway.