文献类型：期刊文献

中文题名：黄芪防治神经退行性疾病的作用及机制研究进展

英文题名：Research Progress on the Effect and Mechanism of Astragali Radix on Neurodegenerative Diseases

作者：彭婷[1];刘圆圆[2];靳晓杰[1,3];李越峰[1,3];姚娟[1,3]

第一作者：彭婷

机构：[1]甘肃中医药大学药学院,兰州730000;[2]甘肃中医药大学基础医学院,兰州730000;[3]西北中藏药省部共建协同创新中心,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2023

卷号：40

期号：23

起止页码：3308

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(82104370,81960713,82160750);甘肃省自然科学基金项目(21JR1RA270);甘肃省中医药研究中心开放课题(zyzx-2020-17)。

语种：中文

中文关键词：黄芪;神经保护;黄芪多糖;黄芪皂苷;研究进展

外文关键词：Astragali Radix;neuroprotection;astragalus polysaccharides;astragalus saponins;research progress

摘要：神经退行性疾病作为一种以神经元退化与死亡为特征的神经系统疾病,严重威胁着人类的健康,因其发病机制复杂,治疗药物效果不佳,故长期以来备受关注。现代研究发现,黄芪具有保护心脑血管,调节免疫,抗氧化,抗衰老等药理作用,并且黄芪神经保护的作用已被多项科学研究充分证明,本文综述了黄芪常用复方及制剂、黄芪中活性成分在防治神经退行性疾病方面的主要药理作用及机制,以期为黄芪在神经退行性疾病中的临床应用和基础研究提供参考。
As a kind of nervous system disease characterized by neuronal degeneration and death,neurodegenerative diseases pose a serious threat to human health.Due to its complex pathogenesis and poor therapeutic effect,neurodegenerative diseases have long attracted much attention.Modern studies have found that Astragali Radix has pharmacological effects such as cardiovascular and cerebrovascular protection,immune regulation,antioxidant and anti-aging,and its neuroprotective effect has been fully proved by a variety of scientific studies.This paper reviews the main pharmacological effects and mechanisms of commonly used Astragali Radix compounds and preparations and active ingredients of astragalus in the prevention and treatment of neurodegenerative diseases.In order to provide reference for the clinical application and basic research of Astragali Radix in neurodegenerative diseases.