文献类型：期刊文献

英文题名：Non-linear association between serum 25-hydroxyvitamin D levels and cardiovascular outcomes: Evidence from NHANES and mendelian randomization analysis

作者：Li, Jingwei[1];Song, Zhongyang[2,3];Hu, Yiming[1];Yan, Jingnan[1];Shen, Yanyun[1];Qi, Yafeng[1];Xu, Qian[1];Zhang, Lumei[1];Zhao, Bing[1];Zhang, Maofu[1];Zhang, Zhiming[4]

第一作者：李佳蔚

通信作者：Zhang, ZM[1]

机构：[1]Gansu Univ Chinese Med, Coll Clin Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]Gansu Prov Cardiovasc Dis Res Inst, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China;[4]Gansu Prov Hosp Tradit Chinese Med, 518 Guazhou Rd, Lanzhou 730071, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, 518 Guazhou Rd, Lanzhou 730071, Peoples R China.

年份：2025

卷号：35

期号：10

外文期刊名：NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

收录：;Scopus(收录号：2-s2.0-105009936425);WOS:【SCI-EXPANDED(收录号:WOS:001575055200009)】；

基金：Funding This research was supported by the National Natural Science Foundation (Grant No. 81660730) .

语种：英文

外文关键词：25-hydroxyvitamin D; Cardiovascular disease; NHANES; Mendelian randomization; Dose-response relationship; Epidemiology; Non-linear association

摘要：Background and aims: The relationship between serum 25-hydroxyvitamin D (25(OH)D) and cardiovascular health is more complex than previously recognized. Observational studies link 25(OH)D deficiency to cardiovascular risk, while intervention trials show inconsistent results. This study evaluates the association between 25 (OH)D levels and cardiovascular outcomes using both observational and genetic approaches, focusing on nonlinear relationships and causality. Methods and results: We obtained data from the National Health and Nutrition Examination Survey (NHANES) 2021-2023, including 4792 adults aged >= 18 years with complete 25(OH)D measurements and cardiovascular assessments. Analysis across 25(OH)D quartiles (<= 56.7, 56.8-78.1, 78.2-103.0, >103.0 nmol/L) showed distinct patterns. In fully adjusted models, the highest quartile had significantly elevated risks for coronary heart disease (CHD) (OR = 1.97, 95 % CI: 1.34-2.89, P <0.001) and hypertension (OR = 1.48, 95 % CI: 1.28-1.71, P <0.001) compared to the lowest quartile. Mendelian randomization analysis provided evidence of causal relationships with CHD ((3 = -0.465, SE = 0.137, P = 7.08 x 10(-4)) and heart failure ((3 = -0.088, SE = 0.035, P = 0.011). Restricted cubic spline analyses revealed U-shaped associations, with optimal 25(OH)D levels (56.8-78.1 nmol/ L) corresponding to lowest cardiovascular risk. Conclusion: Our findings reveal non-linear relationships between 25(OH)D and cardiovascular outcomes, with both observational and genetic evidence indicating causality for certain conditions. Results suggest that the optimal 25(OH)D range for cardiovascular health may be narrower than previously thought, highlighting the importance of maintaining balanced levels through personalized supplementation strategies.