文献类型：期刊文献

英文题名：Research progress of natural medicine Astragalus mongholicus Bunge in treatment of myocardial fibrosis*

作者：Ren, Chunzhen[1,2,3];Zhao, Xinke[2,3,4];Liu, Kai[1,2,3];Wang, Lirong;Chen, Qilin[1,2,3];Jiang, Hugang[1,2,3];Gao, Xiang;Lv, Xinfang;Zhi, Xiaodong[1,2,3,4];Wu, Xue[5];Li, Yingdong[1,2,3]

第一作者：任春贞;Ren, Chunzhen

通信作者：Li, YD[1]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China;[2]Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou 730000, Peoples R China;[3]Key Clin specialty Natl Hlth Commiss Peoples Repub, Key Specialized Cardiovasc Lab Natl Adm Tradit Chi, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China;[5]Lanzhou Univ, Hosp 2, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：305

外文期刊名：JOURNAL OF ETHNOPHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85146129647);WOS:【SCI-EXPANDED(收录号:WOS:000995112400001)】；

基金：This is work was funded by the 2021 Jiaoyu Jiebang Guashuai Project (No. 2021jyjbgs-03) , 2022 Gansu Province Longyuan Youth Innovation and Entrepreneurship Talent Project, 2022 Gansu Province outstanding graduate student "Innovation Star" project (NO. 2022CXZX- 736) , and National Natural Science Foundation of China (NO. 81873132) .

语种：英文

外文关键词：Astragalus mongholicus Bunge; Active ingredients of Astragalus mongholicus; Bunge; MF; Astragalus mongholicus Bunge compound; preparation; Research progress

摘要：Ethnopharmacological relevance: Myocardial fibrosis (MF) is a common pathological manifestation of many car-diovascular diseases at a certain stage, with excessive accumulation of collagen fibers, excessive increase in collagen content, and a significant increase in collagen volume as the main pathological changes. There are currently no effective drugs for the treatment of myocardial fibrosis. Traditional Chinese medicine (TCM), the main component of the medical practice used for more than 5000 years, especially in China, often exerts a wider action spectrum than previously attempted options in treating human diseases. In recent times, the great po-tential of TCM in the treatment of MF has received much attention. Especially many experimental studies on the treatment of MF by Astragalus mongholicus Bunge have been conducted, and the effect is remarkable, which may provide more comprehensive database and theoretical support for the application of Astragalus mongholicus Bunge in the treatment of MF and could be considered a promising candidate drug for preventing MF. Aim of the review: This review summarizes the chemical components of Astragalus mongholicus Bunge, Astragalus mongholicus Bunge extract, Astragalus mongholicus Bunge single prescription, and Astragalus mongholicus Bunge compound preparation in the treatment of MF, and provides comprehensive information and a reliable basis for the exploration of new treatment strategies of botanical drugs in the therapy of MF. Methods: The literature information was obtained from the scientific databases on ethnobotany and ethno-medicines (up to August 2022), mainly from the PubMed, Web of Science, and CNKI databases. The experimental studies on the anti-myocardial fibrosis role of the effective active components of Astragalus mongholicus Bunge and the utility of its compound preparation and the involved mechanisms were identified. The search keywords for such work included: "myocardial fibrosis" or "Cardiac fibrosis ", and "Astragalus mongholicus Bunge", "extract," or "herb". Results: Several studies have shown that the effective active components of Astragalus mongholicus Bunge and its formulas, particularly Astragaloside IV, Astragalus polysaccharide, total saponins of Astragalus mongholicus Bunge, triterpenoid saponins of Astragalus mongholicus Bunge, and cycloastragenol, exhibit potential benefits against MF, the mechanisms of which appear to involve the regulation of inflammation, oxidant stress, and pro -fibrotic signaling pathways, etc. Conclusion: These research works have shown the therapeutic benefits of Astragalus mongholicus Bunge in the treatment of MF. However, further research should be undertaken to clarify the unconfirmed chemical composition and regulatory mechanisms, conduct standard clinical trials, and evaluate the possible side effects. The insights in the present review provided rich ideas for developing new anti-MF drugs.Thesis: Myocardial fibrosis (MF) with excessive accumulation of collagen fibers, excessive increase in collagen content, and a significant increase in collagen volume as the main pathological changes is a common pathological manifestation of many cardiovascular diseases at a certain stage, which seriously affects cardiac function. At present, there is still a lack of effective drugs for the treatment of MF. Traditional Chinese medicine (TCM), the main component of the medical practice used for more than 5000 years especially in China, often exerts wider action spectrum than previously attempted options in treating human diseases. In recent times, the great po-tential of TCM in the treatment of MF has received much attention. Especially many experimental studies on the treatment of MF by Astragalus mongholicus Bunge have been conducted, and the effect is remarkable, which may provide more comprehensive data base and theoretical support for the application of Astragalus mongholicus Bunge in the treatment of MF and could be considered a promising candidate drug for preventing MF.