文献类型：期刊文献

中文题名：治萎防变胶囊对气虚血瘀型慢性萎缩性胃炎模型大鼠生长抑素和免疫功能的影响

英文题名：Effect of Zhiweifangbian Capsule on Somatostatin and Immune Function in Chronic Atrophic Gastritis Rats with Qi-deficiency and Blood-statsis

作者：张虹[1];成映霞[2];段永强[2];程容[2];朱立鸣[2]

第一作者：张虹

机构：[1]甘肃省第二人民医院;[2]甘肃中医学院

第一机构：甘肃省第二人民医院

年份：2011

卷号：18

期号：6

起止页码：35

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2011_2012】；

基金：甘肃省中医管理局科技计划项目(07-GZK-07);甘肃中医学院中青年基金项目(05ZQ-03/09ZQ-09)

语种：中文

中文关键词：慢性萎缩性胃炎;治萎防变胶囊;生长抑素;脾脏指数;胸腺指数;大鼠

外文关键词：chronic atrophic gastritis； Zhiweifangbian Capsule； somatostatin； spleen index； thymus index； rats

摘要：目的观察治萎防变胶囊对气虚血瘀型慢性萎缩性胃炎模型大鼠生长抑素和免疫功能的影响,探讨其作用机制。方法采用综合法成功复制慢性萎缩性胃炎动物模型。将60只大鼠随机分为空白组、模型组、维酶素组和治萎防变胶囊大、中、小剂量组,分别施药治疗后对各组大鼠胃黏膜组织、血清生长抑素及脾脏、胸腺指数进行检测。结果与空白组比较,模型组大鼠生长抑素水平显著升高(P<0.01),脾脏、胸腺指数显著下降(P<0.05);与模型组比较,治萎防变胶囊大、中、小剂量组可显著降低生长抑素水平(P<0.05),显著提高脾脏指数(P<0.05),且以治萎防变胶囊大剂量组作用显著。结论治萎防变胶囊具有增强大鼠免疫功能而有利于消除胃黏膜炎症,促进生长抑素正常分泌而调节胃酸、胃黏膜黏液分泌,增加胃黏膜血流量、营养和修复胃黏膜的作用。
Objective To investigate the effect of Zhiweifangbian Capsule on somatostatin in gastric tissue and serum,thymus and spleen index in chronic atrophic gastritis rats with qi-deficiency and blood-statsis, and explore its mechanism.Methods Model of chronic atrophic gastritis was established with synthetic method.Sixty rats were randomly divided into normal group,model group,Weimeisu group and high dose of Zhiweifangbian,middle dose of Zhiweifangbian,low dose of Zhiweifangbian group,and given corresponding drugs.The levels of somatostatin in gastric tissue and serum,thymus and spleen indexes of each group were detected.Results In model group,levels of somatostatin in gastric tissue and serum were much higher than those of normal group（P〈0.01）,thymus and spleen indexes much lower than that of normal group（P〈0.05）.Compared with model group,Zhiweifangbian Capsule could decrease the content of somatostatin in gastric tissue and serum（P〈0.05）,and increase spleen index（P〈0.05）significantly. Conclusion Zhiweifangbian Capsule has functions of strengthening immune function,promoting somatostatin and gastric acid secretion,ameliorating gastric mucosal blood supply.