文献类型：期刊文献

英文题名：Different interventions for the treatment of patent ductus arteriosus in children: a protocol for a network meta-analysis

作者：Zhang, Xin[1,2];Hou, Xiao-Dong[2,3];Wang, Wen-Xin[1,2];Yi, Kang[2,3];Wang, Xin-Kuan[2,3];Ding, Fan[2,3];Li, Xin-Xin[2,3];You, Tao[2,3]

第一作者：Zhang, Xin;张欣

通信作者：You, T[1];You, T[2]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[2]Gansu Int Sci & Technol Cooperat Base Diag & Treat, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Dept Cardiovasc Surg, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Int Sci & Technol Cooperat Base Diag & Treat, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Cardiovasc Surg, Lanzhou, Peoples R China.

年份：2023

卷号：12

期号：1

外文期刊名：SYSTEMATIC REVIEWS

收录：;Scopus(收录号：2-s2.0-85149343591);WOS:【SCI-EXPANDED(收录号:WOS:000943029300003)】；

基金：Natural Science Foundation of Gansu Province (22JR5RA655, 21JR1RA027).

语种：英文

摘要：Introduction Patent ductus arteriosus (PDA) is one of the most common congenital heart diseases. Once the PDA is diagnosed, it needs to be dealt with in time. At present, main methods include pharmacological treatment, surgical closure, and interventional closure for treatment of PDA. However, the effect of different interventions in PDA management is still controversial. Thus, our study aims to assess the effectiveness of different interventions together and estimate the sequence of these therapies for PDA children. Meanwhile, it is necessary to conduct a Bayesian network meta-analysis to compare the safety of different interventions comprehensively. Methods and analysis To the best of our knowledge, this is the first Bayesian network meta-analysis comparing the efficacy and safety of different interventions for the treatment of PDA. PubMed, Embase, Cochrane Library, Web of Science, gray literature, and trial registry databases were searched from inception to December 2022. We will extract and report data according to methodological guidelines for Bayesian network meta-analysis by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). Primary PDA closure, overall PDA closure, technical success, surgical success rate, mortality during hospital stay, operation time, intensive care unit stay, intraoperative radiation dose, radiation exposure time, total postoperative complication rate, and postoperative major complication rate will be defined as the outcomes. The quality of all random studies will be assessed using ROB, and quality of evidence for all outcomes will be judged by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Ethics and dissemination The results will be disseminated through peer-reviewed publication. Since no private and confidential patient data will be contained in the reporting, there are no ethical considerations associated with this protocol.