文献类型：期刊文献

英文题名：Current status and new experimental diagnostic methods of invasive fungal infections after hematopoietic stem cell transplantation

作者：Tang, Zhenhua[1];Wang, Haitao[2];Liu, Yuankai[3];Wang, Chen[3];Li, Xinye[4];Yang, Qiong[3]

第一作者：Tang, Zhenhua

通信作者：Yang, Q[1];Li, XY[2]

机构：[1]Xinjiang Univ, Coll Life Sci & Technol, Xinjiang Key Lab Biol Resources & Genet Engn, Urumqi 830046, Peoples R China;[2]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Dept Hematol, Beijing 100071, Peoples R China;[3]Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Resource & Mol Dev, Beijing 100875, Peoples R China;[4]Gansu Univ Chinese Med, Lanzhou Petrochem Gen Hosp, Affiliated Hosp 4, Lanzhou 730060, Gansu, Peoples R China

第一机构：Xinjiang Univ, Coll Life Sci & Technol, Xinjiang Key Lab Biol Resources & Genet Engn, Urumqi 830046, Peoples R China

通信机构：[1]corresponding author), Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Resource & Mol Dev, Beijing 100875, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Lanzhou Petrochem Gen Hosp, Affiliated Hosp 4, Lanzhou 730060, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：206

期号：5

外文期刊名：ARCHIVES OF MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-85191748853);WOS:【SCI-EXPANDED(收录号:WOS:001209754900001)】；

基金：No Statement Available

语种：英文

外文关键词：Hematopoietic stem cell transplantation; Invasive fungal infection; Fungal infection detection technology; Cationic conjugated polymer-based fluorescence resonance energy transfer

摘要：Invasive fungal infections (IFIs) are common and life-threatening complications in post-hematopoietic stem cell transplantation (post-HSCT) recipients, Severe IFIs can lead to systemic infection and organ damage, which results in high mortality in HSCT recipients. With the development of the field of fungal infection diagnosis, more and more advanced non-culture diagnostic tools have been developed, such as glip biosensors, metagenomic next-generation sequencing, Magnetic Nanoparticles and Identified Using SERS via AgNPs+ , and artificial intelligence-assisted diagnosis. The advanced diagnostic approaches contribute to the success of HSCT and improve the overall survival of post-HSCT leukemia patients by supporting therapeutical decisions. This review provides an overview of the characteristics of two high-incidence IFIs in post-HSCT recipients and discusses some of the recently developed IFI detection technologies. Additionally, it explores the potential application of cationic conjugated polymer fluorescence resonance energy transfer (CCP-FRET) technology for IFI detection. The aim is to offer insights into selecting appropriate IFI detection methods and gaining an understanding of novel fungal diagnostic approaches in laboratory settings.